摘要
目的前瞻性分析75岁以上高龄心房颤动患者应用华法林的安全性及疗效。方法随机纳入接受华法林抗凝治疗的心房颤动患者50例,按照统一的给药方案应用华法林及监测血凝,把国际标准化比值控制在1.5~2.5之间。并同期纳入150例未接受抗凝治疗的房颤患者作为对照,随访2年,观察华法林的安全性和疗效。并计算经济成本。结果 200例患者中发生脑卒中为56例,以是否发生脑卒中为分组,其脑卒中病史、高血压、抗栓治疗方案差异有统计学意义(P<0.05)。以是否应用华法林抗凝为分组,脑卒中发病有差异(P<0.05),出血事件差异无统计学意义(P>0.05)。其经济成本远低于新型抗凝药。结论高龄患者应用华法林抗凝,采用宽松抗凝方案可降低脑卒中的发生,不增加出血风险。且经济负担低,易于执行。
Objective: To prospectively analyze the safety and efficacy of warfarin in patients with atrial fibrillation over the age of 75 years. Method: 50 patients with atrial fibrillation who received warfarin anticoagulation were randomly enrolled,taked warfarin and monitoring of blood coagulation according to a unified dosing regimen. The international normalized ratio( INR) is controlled between 1. 5 ~ 2. 5,in the meantime,150 patients with atrial fibrillation who did not receive anticoagulation were included as controls. After 2 years of follow-up,the safety and efficacy of warfarin were observed,and the economic cost was calculated. Results: There were 56 cases of stroke in 200 patients. The difference in stroke history,hypertension and antithrombotic therapy was statistically significant( P < 0. 05). There were differences in the incidence of stroke with regard to the use of warfarin anticoagulation( P < 0. 05). The difference in bleeding events was not statistically significant( P > 0. 05). Its economic cost is far lower than that of new anticoagulants. Conclusion: Elderly patients with warfarin anticoagulation,the use of loose anticoagulant regimen can reduce the incidence of stroke,without increasing the risk of bleeding. And the economic burden is low,easy to implement.
出处
《泰山医学院学报》
CAS
2017年第12期1393-1395,共3页
Journal of Taishan Medical College
关键词
高龄患者
房颤
抗凝
华法林
elderly patients
atrial fibrillation
anticoagulation
warfarin
