摘要
目的研究奥卡西平致不良反应的特征,为奥卡西平安全合理用药提供参照。方法以"奥卡西平"、"不良反应"、"致"为检索词,检索万方数据库、中国期刊网全文数据库、维普中文期刊全文数据库,按纳入与排除标准筛选29篇文献,分析文献并提取相关病例归纳分析。结果提取病例163例,不良反应发生于从儿童到老年各年龄段,原患疾病主要为癫痫,不良反应多发于用药后3~30 d内,累及系统-器官损害主要为皮肤及其附件系统、神经和精神系统、营养障碍等,不良反应以皮疹、头痛及低钠血症等最为常见。结论关注奥卡西平不良反应,加强临床合理用药指导,确保用药安全。
Objective Through investigating the characteristics and mechanism of adverse drug reactions（ADRs）induced by oxcarbazepine, to find its risk factors and provide technical support for safe and rational use of drugs in clinic.Methods Using ＂oxcarbazepine＂ 、 ＂adverse reaction＂ and ＂to＂ as key words to search and retrieve articles in the Wanfang database、CNKI database and VIP Chinese full-text database. 29 references which met the inclusion criteria were extracted and analyzed. Results 163 cases were extracted. Adverse reactions occurred in all ages from children to the elderly. The major illness was epilepsy. ADRs occurred more frequently within 3~30 d. Systems and organs mainly involved in adverse reactions were skin and its accessory system, nervous and mental system and nutritional disorders etc. Arrhythmia, rash, headache and hyponatremia are the most common reported adverse reactions. Conclusion It is important to pay attention to the adverse reactions caused by oxcarbazepine, strengthen clinical rational use of drugs, in order to ensure the safe drug use in clinic.
出处
《中国药物警戒》
2017年第11期683-686,共4页
Chinese Journal of Pharmacovigilance
关键词
奥卡西平
不良反应
文献分析
oxcarbazepine
adverse drug reactions
literature review
