摘要
目的综述蛋白酶激活受体2(protease-activated receptor 2,PAR-2)在骨关节炎(osteoarthritis,OA)发病机制中的研究进展。方法广泛查阅近年国内外有关PAR-2在OA发生发展过程中作用机制的文献,并进行综合分析。结果 PAR-2的异常激活在OA发生发展过程中发挥重要作用。激活的PAR-2可以通过调节炎性因子、代谢因子、致痛因子等的生成及释放,参与OA关节软骨、软骨下骨及滑膜的生理和病理变化以及疼痛的产生与传导。结论 PAR-2参与OA的发生发展已被证实,但由于PAR-2的复杂性以及分布的广泛性,需对其在OA进程中的具体作用及各通路间的相互影响进行深入研究,阐明PAR-2参与OA病变过程的潜在病理生理机制,以期探索新的有效控制OA发生的作用靶点。
Objective To review the research progress on protease-activated receptor 2 （PAR-2） in the patho- genesis of osteoarthritis （OA）. Methods The relevant literature about the mechanism of PAR-2 in the occurrence and development of OA in recent years was extensively reviewed and comprehensively analyzed. Results Abnormal activation of PAR-2 plays an important role in responses to occurrence and development of OA. Through regulating production and releasing of a variety of cytokines （such as inflammatory factors, metabolic factors, pain factors, etc.）, the PAR-2 can involve in pathophysiological progression of OA articular cartilage, subchondral bone, and synovial membrane, as well as occurrence and transmission of pain. Conclusion PAR-2 participation in the development of OA has been confirmed. However, since PAR-2 is complicated and widespread, it is necessary to study the specific role of PAR-2 and the interaction between various signal pathways in the progression of OA, and to elucidate the potential pathophysiological mechanisms of PAR-2 participating in the process of OA, in the hope of exploring the new targets for the effective control of OA.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2017年第12期1517-1522,共6页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(31671235)
河北省自然科学基金重点项目(H2016209176)
河北省政府资助临床医学优秀人才培养和基础课题研究项目(361036)
唐山市科技创新团队培养计划(15130208C)
河北省第二批青年拔尖人才支持计划~~
