摘要
目的探讨Ⅱ型糖尿病患者血尿酸水平与新发心血管疾病及糖尿病肾病的相关性。方法筛选西安市中心医院2014年11月~2016年11月280例糖尿病患者,以血尿酸水平为基准分为高尿酸组和正常尿酸组,各140例,检测两组患者心血管相关指标和肾损害指标,评价血尿酸水平与新发心血管疾病及糖尿病肾病的关系。结果高尿酸组患者的颈动脉内-中膜厚度、尿白蛋白/肌酐比值及甘三油酯高于正常尿酸组,差异有统计学意义(P<0.01);高尿酸组高血压、冠状动脉粥样硬化及糖尿病肾病的发生率高于正常尿酸组(P<0.05);高尿酸组冠状动脉粥样硬化和糖尿病肾病的发生时间分别为12.58±2.36月和11.75±1.96月,短于正常尿酸组(P<0.05);多元回归分析显示血尿酸水平是颈动脉内-中膜厚度、尿白蛋白/肌酐比值的主要影响因素。结论Ⅱ型糖尿病患者血尿酸水平与新发心血管疾病及糖尿病肾病呈正相关,随着血尿酸水平升高新发心血管疾病及糖尿病肾病的概率更高、发病时间更早。
Objective To explore the relationship between serum uric acid level with new emerging cardiovascular disease and diabetic nephropathy in patients with type II diabetes. Methods A total of 280 patients with type II diabetic in xi＇an central hospital from November 2014 to November 2016 were chosed as subject. Accrording to the level of serum uric acid, patients were divide into hyperuricemia group and normal uric acid group, with 140 cases in each group. Cardiovascular and renal damage indexes were detected in two groups, which were used to evaluate the relationship between serum uric acid level with newly emerging cardiovascular disease and diabetic nephropathy. Results The carotid artery medial thickness （IMT）, urinary albumin/creatinine ratio （ACR） and the three oil ester （TG） in hyperuricemia group were significantly higher than those in normal uric acid group （P〈0.01）. The morbidity and occurrence time of cardiovascular disease and diabetic nephropathy in 2 groups showed significant differences （P〈0.05）. Multiple regression analysis showed that serum uric acid level was the main influence factor of IMT and ACR. Conclusion The relationship between serum uric acid level with new emerging cardiovascular disease and diabetic nephropathy was positive. Wish a rising of serum uric acid level the morbidity of new emerging cardiovascular disease and diabetic nephropathy is higher and the occurrence time is earlier.
出处
《分子影像学杂志》
2017年第4期445-448,共4页
Journal of Molecular Imaging
关键词
血尿酸水平
颈动脉内-中膜厚度
尿白蛋白/肌酐比值
心血管疾病
糖尿病肾病
serum uric acid level
carotid artery medial thickness
urinary albumin/creatinine ratio
cardiovascular disease
diabetic nephropathy
