摘要
目的探讨丹红注射液联合麝香保心丸治疗心血瘀阻型冠心病心绞痛的临床效果及对患者血管内皮功能和炎症因子的影响。方法采用随机数字表法将128例心血瘀阻型冠心病心绞痛患者分为对照组(64例)和治疗组(64例)。所有患者均给予低盐低脂饮食、抗凝、降血脂等基础治疗,对照组静脉注射丹红注射液,治疗组在对照组基础上加服麝香保心丸。治疗1个月后,评价两组患者的临床疗效,检测治疗前后两组患者脂联素(APN)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、内皮素(ET)、血栓素B2(TXB2)及血液流变学水平,以及治疗过程中的不良反应情况。结果治疗1个月后,治疗组总有效率为92.19%,显著高于对照组的81.25%(P<0.05);两组患者APN、NO水平较治疗前均明显升高(P<0.05),且治疗组较对照组升高更明显(P<0.05);两组患者TNF-α、hs-CRP、ET、TXB2及血浆黏度、全血黏度、血细胞比容、纤维蛋白原水平较治疗前均明显降低(P<0.05),且治疗组较对照组降低更明显(P<0.05);两组治疗过程中均无恶心、呕吐、乏力、腹泻、头痛等不良反应发生。结论丹红注射液联合麝香保心丸能有效降低心血瘀阻型冠心病心绞痛患者TNF-α、hs-CRP、ET、TXB2水平,升高APN、NO水平,发挥抗炎和改善血管内皮功能,安全有效,值得临床推广应用。
Objective To explore the clinical effects of the combined therapy of danhong injection and shexiang baoxin pills on coronary heart disease with angina pectoris of heart blood stagnation and the impacts on vascular endothelia function and inflammatory factors in the patients. Methods According to the random number table,128 patients of coronary heart disease with angina pectoris of heart blood stagnation were divided into a control group（ 64 cases） and a treatment group（ 64 cases）. All of the patients received the basic treatment with low-salt and low-fat diet,anticoagulation and anti-hyperlipidemia. In the control group,the intravenous infusion of danhong injection was used. In the control group,on the basis of the treatment as the control group,shexiang baoxin pills were prescribed. After 1-month treatment,the clinical therapeutic effects were assessed in the two groups. The levels of APN,NO,TNF-α,hs-CRP,ET,TXB2,hemorheologic indexes were determined before and after treatment,as well as the adverse reactions during treatment. Results After 1-month treatment,the total effective rate was 92. 19% in the treatment group,significantly higher than 81. 25% in the control group（ P〈0. 05）. The levels of APN and NO were increased remarkably as compared with those before treatment in the two groups（ P〈0. 05）. The increase was much more remarkably in the treatment group compared with the control group（ P〈0. 05）. The levels of TNF-α,hs-CRP,ET,TXB2,as well as plasma viscosity,whole blood viscosity,haematocrit and fibrinogen were all reduced remarkably as compared with those before treatment in the two groups（ P〈0. 05）. The reducing in the treatment group was more remarkable than the control group（ P〈0. 05）. During treatment,the adverse reactions did not occur,such as nausea,vomiting,lassitude,diarrhea and headache. Conclusion The combined therapy of danhong injection and shexiang baoxin pills effectively reduces the levels of TNF-α,hs-CRP,ET and TXB2 and increases the levels of APN and NO in the patients with coronary heart disease with angina pectoris of heart blood stagnation. This therapy plays the role on anti-inflammation and improving vascular endothelial function. It is safe and effective and deserves to be promoted in clinical practice.
出处
《世界中西医结合杂志》
2017年第11期1576-1579,共4页
World Journal of Integrated Traditional and Western Medicine
关键词
冠心病
心绞痛
心血瘀阻型
丹红注射液
麝香保心丸
血管内皮
炎症因子
Coronary Heart Disease
Angina Pectoris
Heart Blood Stagnation
Danhong Injection
Shexiang Baoxin Pills
Vascular Endothelia Function
Inflammatory Factors
