摘要
目的探讨原发性肝癌患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平与抑郁症发生因素的相关性。方法采用回顾性分析研究,选取陕西省人民医院2015年9月~2016年9月收治的原发性肝癌患者43例,使用抑郁自评量表评定,分为抑郁组和非抑郁组,用ELISA试剂盒检测血清中VEGF水平,分析抑郁、年龄、性别因素与血清VEGF浓度关系。结果发生抑郁患者血清中VEGF水平(86.21±19.52pg/ml)明显高于未发生抑郁的患者(48.31±9.16pg/ml),经t检验,差异有统计学意义(t=-2.968,P=0.005)。性别分组检测患者血清VEGF水平t=0.079,P=0.938;不同年龄段分组检测患者的血清VEGF水平,经多组方差分析F=0.618,P=0.655,年龄和性别因素对于原发性肝癌血清中VEGF的水平,差异无统计学意义。结论原发性肝癌发生抑郁的患者,与血清VEGF水平存在相关性,提示血清VEGF水平可能成为原发性肝癌预后检测指标,对此类患者及早进行心理干预,可能改善肿瘤并发抑郁患者的预后。
Objective To investigate the correlation between serum vascular endothelial growth factor（VEGF）and the fac-tors of depression in patients with primary liver cancer（HCC）.Methods The retrospective analysis was about 43 cases of primary liver cancer patients of Shaanxi Provincial People＇s Hospital,from September 2015 to September 2016.The self-rat-ing depression scale was used to evaluate the patients with depression and non-depression group.By ELISA kits,test VEGF levels,analysis of depression,age,gender and serum VEGF concentration.Results The level of VEGF in patients with de-pression was 86.21±19.52 pg/ml,which was significantly higher than that in patients without depression（48.31±9.16 pg/ml）by t test（t=-2.968,P=0.005）.The levels of serum VEGF in patients with different gender groups were meas-ured by t test（t=0.079,P=0.938）.And the serum levels of VEGF were measured in patients with different age groups by multiple sets of variance analysis（F=0.618,P=0.655）.For age and gender,there was no significant difference in serum VEGF level between HCC.Conclusion By HCC,it was related between depression and the level of serum VEGF,and it suggests that serum level of VEGF may become the prognosis of primary liver cancer detection index for these patients.Giv-ing psychological interventions earlier,may improve the prognosis of cancer patients with depression.
出处
《现代检验医学杂志》
CAS
2017年第6期96-98,共3页
Journal of Modern Laboratory Medicine
基金
陕西省自然科学基金面上项目:2014JM2-3035
