摘要
目的探讨可能与原发性醛固酮增多症(primary aldosteronism,PA)早期肾脏损害相关的临床因素。方法通过61例原发性醛固酮增多症患者的横断面临床资料,分析可能与估算肾小球滤过率(estimated glomerular filtration rate,eGFR)下降独立相关的临床因素。结果 57例符合研究条件的PA患者纳入此项分析,其中54.4%(31/57)的患者eGFR<90 m L/min/1.73 m^2。单因素分析表明,低血清钾离子浓度(P=0.038)、高血肌酐浓度(P=0.047)、高血尿酸浓度(P=0.044)、高尿β_2微球蛋白(P<0.001)、以及高尿微量蛋白(P=0.017)与eGFR下降相关。多因素分析表明,高水平尿β_2微球蛋白(OR:1.044,95%CI:1.016~1.173,P=0.002)独立的与PA患者eGFR下降相关。结论尿β2微球蛋白检测可能是预测eGFR下降及肾脏功能损伤的独立风险因素。
Objective To explore the clinical factors that may be associated with early renal impairment in patients with primary aldosteronism. Methods The clinical data of 61 patients with primary aldosteronism were analyzed. To explore the clinical factors that may be associated with the decrease of estimated glomerular filtration rate（ e GFR）.Results Fifty-seven patients were included in this analysis,54. 4%（ 31/57） patients＇ s e GFR 〈90 m L/min/1.73 m^2. Univariate analysis revealed that lower serum potassium concentration（ P = 0. 038）,higher serum creatinine concentration（ P = 0. 047）,higher serum uric acid concentration（ P = 0. 044）,higher uric β_2 microglobulin（ P〈 0.001）,and higher urinary microprotein（ P = 0. 017） were associated with decreased e GFR in patients with PA. Multivariate analysis showed that higher level of uric β_2-microglobulin（ OR： 1. 044,95% CI： 1. 016-1. 173,P = 0.002） was independently associated with decreased e GFR in patients with PA. Conclusion Urine β_2 microglobulin may be an independent risk factor for predicting e GFR decline and renal dysfunction in patients with primary aldosteronism.
出处
《延安大学学报（医学科学版）》
2017年第4期19-22,27,共5页
Journal of Yan'an University:Medical Science Edition
