摘要
目的探讨亚胺培南西司他丁钠治疗重症肺炎的临床效果。方法选取2013年5月至2016年8月无锡市人民医院收治的重症肺炎患者60例,按治疗方法分为观察组和对照组,每组30例。对照组患者给予注射用头孢哌酮舒巴坦治疗,观察组患者给予亚胺培南西司他丁钠治疗,疗程7~10 d。分别于治疗前后测定2组患者血清降钙素原(PCT)和C反应蛋白(CRP)水平,并进行咳嗽评分;治疗结束后评定2组患者临床疗效,并记录患者不良反应。结果治疗前2组患者血清PCT、CRP水平比较差异均无统计学意义(P>0.05),2组患者治疗后血清PCT、CRP水平显著低于治疗前(P<0.05),治疗后观察组患者血清PCT、CRP水平显著低于对照组(P<0.05)。治疗前2组患者咳嗽评分比较差异无统计学意义(P>0.05),2组患者治疗后咳嗽评分显著低于治疗前(P<0.05),治疗后观察组患者咳嗽评分显著低于对照组(P<0.05)。观察组和对照组患者治疗总有效率分别为93.33%(14/15)、60.00%(9/15),观察组患者治疗总有效率显著高于对照组(χ~2=4.658,P<0.05)。2组患者不良反应发生率均为6.67%,差异无统计学意义(χ~2=0.000,P>0.05)。结论亚胺培南西司他丁钠能够显著减轻重症肺炎患者的炎症反应及临床症状,疗效显著。
Objective To investigate the clinical effect of imipenem and cilastatin sodium in the treatment of severe pneumonia. Methods Sixty patients with severe pneumonia were selected from May 2013 to August 2016 in Wuxi People＇ s Hospital. The patients were divided into observation group and control group according to the treatment method,30 cases in each group. The patients in the control group were treated with cefoperazone and sulbactam injection,and the patients in the observation group were treated with imipenem and cilastatin sodium. The levels of serum procalcitonin（ PCT） and C-reactive protein（ CRP） were measured,and the cough score was performed in the two groups before and after treatment. The clinical effect was evaluated after treatment,and the adverse reactions of the patients were recorded in the two groups. Results There were no significant difference in the levels of serum PCT and CRP between the two groups before treatment（ P 0. 05）. The levels of serum PCT and CRP after treatment were significantly lower than those before treatment in the two groups（ P 0. 05）. The levels of serum PCT and CRP in the observation group were significantly lower than those in the control group after treatment（ P 0. 05）. There was no significant difference in cough score between the two groups before treatment（ P 0. 05）. The cough score after treatment was significantly lower than that before treatment in the two groups（ P 0. 05）. The cough score in the observation group was significantly lower than that in the control group after treatment（ P 0. 05）. The total effective rate in the observation group and the control group was 93. 33%（ 14/15） and 60. 00%（ 9/15） respectively,the total effective rate in the observation group was significantly higher than that in the control group（ χ~2= 4. 658,P 0. 05）. The incidence of adverse reactions in the two groups was 6. 67%,there was no significant difference in the incidence of adverse reactions between the two groups（ χ~2= 0. 000,P 0. 05）. Conclusion Imipenem and cilastatin sodium can significantly reduce the inflammatory response and clinical symptoms in patients with severe pneumonia,and the curative effect is remarkable.
出处
《新乡医学院学报》
CAS
2017年第12期1128-1130,共3页
Journal of Xinxiang Medical University
