摘要
目的:探讨牙周非手术治疗对慢性牙周炎患者血管内皮功能和动脉僵硬度的影响。方法:选取于我院口腔诊疗中心就诊的慢性牙周炎患者43例(观察组)和健康者86例(健康组)作为研究对象,观察组接受牙周非手术治疗。治疗前测量两组患者的临床参数,治疗3个月后再次测量观察组的临床参数,具体包括临床牙周指数、动脉血流介导血管扩张功能(FMD,反映血管内皮功能)和肱踝脉搏波传导速度(baPWV,反映动脉僵硬度)。结果:观察组患者治疗前的FMD低于健康组[(8.02±3.13)%vs.(11.54±2.69)%],而其baPWV高于健康组[(14.48±1.97)m/s vs.(12.16±1.32)m/s],差异具有统计学意义(P<0.05)。观察组治疗3个月后临床牙周指数明显改善,FMD较治疗前有所升高(9.47±3.65)%,而baPWV较治疗前有所降低(13.51±1.62)m/s,差异具有统计学意义(P<0.05)。Pearson相关分析表明,观察组患者治疗前后FMD和baPWV的变化量均与其牙周探诊深度的变化量呈正相关。结论:牙周非手术治疗可明显改善慢性牙周炎患者的血管内皮功能和动脉僵硬度,可能对其心血管疾病的预防具有一定作用。
Objective： To investigate the effects of nonsurgical periodontal therapy on endothelial function and arterial stiff- ness in patients with chronic periodontitis. Methods： A total of 43 patients with chronic periodontitis （observational group） and 86 healthy subiects （healthy group） admitted at the Oral Diagnosis and Treatment Center o{ our hospital were enrolled. The patients in the observational group received nonsurgical periodontal therapy. The clinical variables, including clinical periodontal indices, flow--mediated dilation （FMD, an indication of endothelial function） and brachial--ankle pulse wave velocity （baPWV, an indication of arterial stiffness）, were measured for the observational and healthy groups before the treatment and again for the observational group after the treatment. Results： Compared with healthy group, observation group showed a significant lower FMD [（8.02 ± 3.13） % vs. （11.54 ± 2.69）%] and higher baPWV [（14.48 ± 1. 97） m/s vs. （12.16±1.32） m/s]. After 3--month treatment, the clinical periodontal indices were obviously improved （P〈0. 05） compared with baseline, with a significantly increased FMD [（9.47±3.65） %, P〈0.05] and decreased baP WV [-（13.51 ± 1.62） m/s, P〈0. 05]. Pearson correlation analysis indicated that both the changes in FMD and baPWV before and after treatment were positively associated with the change in pocket probing depth. Conclusion： Nonsurgical peri- odontal therapy improves endothelial function and arterial stiffness in patients with chronic periodontitis, suggesting that it may benefit the prevention of cardiovascular disease.
出处
《口腔医学研究》
CAS
北大核心
2017年第12期1332-1335,共4页
Journal of Oral Science Research
关键词
牙周炎
非手术治疗
内皮功能
动脉僵硬度
Periodontitis Nonsurgical therapy Endothelial function Arterial stiffness
