摘要
目的:探讨布地奈德吸入联合孟鲁司特钠对小儿哮喘气道功能及血清炎症因子的影响。方法选取支气管哮喘患儿72例作为研究对象,随机分为观察组36例与对照组36例,对照组患儿采用布地奈德气雾剂,观察组在对照组的基础上联合使用孟鲁司特钠,检测并比较两组的气道功能及炎症因子水平。结果治疗前,两组的TEF25%、TEF50%、TEF75%以及FEV1/FVC均无统计学差异(P>0.05);治疗后,两组的TEF25%、TEF50%、TEF75%以及FEV1/FVC均比治疗前提高,且观察组的各指标水平高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患儿的IL-4、IL-6、IL-8、IL-17、TNF-α水平均无统计学差异(P>0.05);治疗后,两组患儿的IL-4、IL-6、IL-8、IL-17、TNF-α水平均比治疗前降低,且观察组各指标水平低于对照组,差异均有统计学意义(P<0.05)。结论布地奈德吸入联合孟鲁司特钠对小儿哮喘气道功能及炎症因子均能达到更有效的改善作用。
Objective:To investigate the effect of budesonide and montelukast on airway function and serum inflammatory factors in children with asthma.Methods:A total of 72 children with bronchial asthma were selected as the subjects,and randomly divided into the observation group(36 cases)and the control group(36 cases).The children in the control group were treated with Budesonide Aerosol,and the observation group was treated with montelukast sodium on the basis of the control group.The airway function and the level of inflammatory factors were detected and compared between the two groups.Results:Before treatment,there was no significant difference in TEF25%,TEF50%,TEF75%and FEV1/FVC between the two groups(P>0.05);After treatment,the TEF25%,TEF50%,TEF75%and FEV1/FVC of the two groups were improved before treatment,and the indexes in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Before treatment,the IL-4,IL-6,IL-8,IL-17,TNF-alpha levels in the two groups were not statistically different(P>0.05);After treatment,the levels of IL-4,IL-6,IL-8,IL-17 and TNF-in the two groups were lower than those before the treatment,and the indexes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Budesonide inhalation combined with montelukast can improve the airway function and inflammatory factors in children with asthma.
出处
《海南医学院学报》
CAS
2018年第1期64-66,70,共4页
Journal of Hainan Medical University
基金
四川省技术创新资助项目(2016EF01280)~~
