摘要
目的探讨低频重复经颅磁刺激(rTMS)治疗原发性失眠症疗效。方法按入院顺序随机将符合ICD-10原发性失眠症诊断标准的98例患者分为研究组(n=49)和对照组(n=49),研究组给予4周真性低频rTMS治疗,对照组给予4周假低频rTMS治疗。治疗前后分别进行多导睡眠监测(PSG)、匹兹堡睡眠指数(PSQI)评定及焦虑自评量表测评(SAS),采用成组检验比较两组临床疗效。结果治疗后研究组各项监测指标有明显改善,观察组各项监测指标无明显变化;两组患者各项指标比较差异显著(P<0.05);两组患者在治疗过程中无严重不良反应发生,两组患者治疗前后心率、血压、心电图无明显变化。结论单纯使用rTMS治疗原发性失眠症安全有效,值得临床推广。
Objective To observe the curative effect of low - frequency repetitive transcranial magnetic stimulation （rTMS） on primary insomnia. Methods 98 cases with primary insomnia of the conformation to ICD -10 Diagnostic Criteria were randomly divided into 2 groups： observation group and control group, 49 in each; low -frequency rTMS treatment was performed on cases in observation group while placebo treatment on cases in control group, the courses for both groups lasted for 4 weeks; Polysomnography monitor （PSG） , Pittsburgh sleep quality index （PSQI） assess- ment and self-rating anxiety test （SAS） were applied to cases in both groups before and after treatment and clinical curative effects of the 2 groups were compared. Results After treatment, the scores and index of the cases in observa- tion group were obviously improved while those in control groups were of no obvious changes, the difference between the 2 groups was of statistical significance （P 〈 0.05 ） ; no occurrence of serious side effects was found in the course in both groups and no obvious changes of heart rate, blood pressure and EGG in the cases in both groups after treatment were observed. Conclusions Single application of rTMS in cases with primary insomnia is of effect and safety, it is worthy of wider clinical application.
出处
《西南军医》
2018年第1期28-32,共5页
Journal of Military Surgeon in Southwest China
关键词
低频
经颅磁刺激
原发性失眠症
low-frequency
transcranial magnetic stimulation
primary insomnia
