摘要
目的利用自发性高血压大鼠(SHR)研究灯盏花乙素(SCU)对高血压影响大鼠血管舒缩反应的作用。方法本研究采用分离14、40周的SHR及其对照品系Wistar-Kyoto大鼠(WKY)的脑基底动脉(BA)和冠状动脉(CA)血管环,应用Wire Myograph血管张力分析系统,测定BA与CA血管环的张力变化,观察SCU对高血压诱导大鼠心脑血管舒缩反应的影响。结果在舒张性反应测定实验中,SCU给药孵育可使血管的舒张效应均显著增强(P<0.001),并且40周的血管舒张性强于14周。在收缩性反应测定实验中,血管的最大收缩率随着SCU孵育浓度的加大依次降低,且SCU组的EC_(50)值明显高于对照组(P<0.05)。结论 SCU对高血压诱导大鼠血管的舒张性与收缩性反应均有一定的影响。
Objective To investigate the effect of Scutellarin （SCU） on angiokinesis responses in rats with spontaneous hypertension （SHR）.Methods In this study,basilar artery （BA） and coronary artery （CA） vascular rings which were iso- lated for 14 weeks and 40 weeks respectively from SHR and its control of Wistar-Kyoto rats （WKY） were applied.Wire Myograph vascular tension analysis system was applied,and tension changes of BA and CA vascular rings were measured.The effects of SCU on hypertension induced cardiovascular and cerebrovascular angiokinesis in rats were observed.Results In the vasodilator reaction assay,the angiokinesis effect of blood vessels was significantly enhanced by incubation with SCU （P〈0.001）,and 40 weeks vasodilation was stronger than that 14 weeks.In vasocontraction response assay,the maximum contraction rate of blood vessels was decreased with the increase of SCU incubation concentration,and the EC50 value in the SCU group was significantly higher than that in the control group （P〈0.05）.Conclusion Scutellarin has certain influence on the vasodilatation and vasocontraction responses induced by hypertension in rats.
出处
《中国当代医药》
2018年第2期4-6,10,共4页
China Modern Medicine
基金
国家自然科学基金资助项目(81560589
81173110)
云南省科技计划项目[2014FA010
2017FE467(-019)]
