摘要
目的探讨浆细胞样尿路上皮癌(PUC)临床病理特征、诊断与鉴别诊断及治疗与预后。方法对6例浆细胞样尿路上皮癌的临床病理和免疫组化特点进行分析比较,并结合相关文献复习。结果 6例PUC组织学形态相似,瘤细胞呈无黏附性弥漫生长,瘤细胞中等大小,形态较单一,类似于浆细胞,胞质嗜酸性、核偏位,核仁不明显。免疫组化:6例CK、CD138、EMA、CK7和CK19均(+);1例CK20(+);2例行HER2染色,其中1例呈(+)。6例E-cadherin、LCA、CD79 a、kappa/lambda和S-100均(-)。结论 PUC是一种非常罕见的尿路上皮癌,由于其缺乏特征性的临床表现及内镜特征而易误诊,但依靠特征性的组织形态学并结合免疫组化有助于其诊断与鉴别诊断。
Objective To discuss the clinicopathological features,diagnosis and differential diagnosis,treatment and prognosis of plasmacytoi durothelial carcinoma（PUC）. Methods The clinicopathological and immunohistochemical expression were retrospectively analyzed in six cases of PUC with review of the literatures. Results Microscopically,the tumor cells of PUC were diffusely discohesive patternless architecture. The tumor cells were medium in size and uniform in shape,with eccentric nuclei,indistinct nucleoli and abundant eosinophilic cytoplasm. Immunohistochemically,6/6 cases showed immunoreactiviy to CD138,EMA,CK7,CK19; one case was positive for CK 20,and 1 of 2 cases studied was positive for HER2; while E-cadherin,LCA,CD79 a,kappa/lambda and S-100 were all negative. Conclusion PUC is a rare urothelial carcinoma. It may be misdiagnosed due to the lack of characteristic clinical manifestations and endoscopic characteristics. Diagnosis and differential diagnosis should be made in combination with immunohistochemical staining and histologic examination.
作者
张冬梅
魏建国
刘勇
梁文清
ZHANG Dong-mei;WEI Jian-guo;LIU Yong;LIANG Wen-qing(Department of Pathology, Fu Xing Hospital, Capital Medical University, Beijing 100038, China;Department of Pathology, Shaoxing People＇s Hospital, Shaoxing 312000, China;Department of Pathology, Jiangxi Province Peoples Hospital, Nanchang 330006, China)
出处
《诊断病理学杂志》
2018年第1期37-40,共4页
Chinese Journal of Diagnostic Pathology
基金
浙江省医药卫生平台计划项目(2016RCA029)
浙江省医药卫生科研项目(2017KY662)
浙江省绍兴市人民医院青年科研基金项目(2017A09)
关键词
尿路上皮癌
浆细胞样
临床病理
免疫组化
Urothelial carcinoma
Plasmacytoid
Clinicopathology
Immunohistochemistry
