摘要
目的:探讨参一胶囊联合腹腔镜解剖性肝段切除术治疗老年原发性肝癌的临床疗效。方法:将74例老年原发性肝癌患者随机分为观察组和对照组各37例,对照组给予腹腔镜解剖性肝段切除术治疗,同时给予安慰剂,而观察组在腹腔镜解剖性肝段切除术的基础上另给予参一胶囊,疗程为2个月。治疗后观察并发症发生情况,评价两组患者近期疗效。治疗前后检测两组患者血清IgG、IgA、IgM、CD3^+、CD4^+等免疫功能指标含量,检测患者血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA-125)及α-岩藻糖苷酶(AFU)等肿瘤标记物水平。结果:观察组与对照组术后并发症发生率分别为14.7%和18.1%,差异无统计学意义。近期疗效结果表明,观察组总有效率为85.3%,明显高于对照组的66.7%(P<0.05)。治疗后,观察组CD3^+、CD4^+、Ig G、Ig A及Ig M等免疫功能指标含量分别为(50.58±9.15)%、(36.23±5.24)%、(15.56±1.95)g/L、(2.45±0.45)g/L及(2.54±0.51)g/L,均明显高于对照组。治疗后,观察组AFP、CEA、CA-125及AFU含量分别为(20.12±2.34)μg/L、(10.97±1.36)μg/L、(24.56±2.19)U/m L及(23.45±2.98)g/L,均明显低于对照组。结论:参一胶囊联合腹腔镜解剖性肝段切除术治疗老年原发性肝癌疗效确切,且能够有效改善患者免疫力。
Objective To investigate the effects of Shenyi Capsule combined with laparoscopic anatomical segmentectomy in the treatment of elderly liver cancer. Methods Elderly liver cancer patients （74 cases） treated in 215 Hospital of Shanxi Nuclear Industry were randomly divided into observation group and control group. The patients in control group were treated with laparoscopic anatomical segmentectomy, and also given placebo. On the base of control group, the patients in observation group were treated by Shenyi Capsule, the course of treatment was two months. After the treatment, the complications were observed and effects were evaluated in the two groups. The levels of immunity index, including IgG, IgA, IgM, CD3＋ and CD4＋ were observed, while the levels of tumor markers containing alpha-fetal protein （AFP）, carcinoembryonic antigen （CEA）, carbohydrate antigen 125 （CA-125） and alpha-dicosidase （AFU） were detected before and after treatment. Results The rate of complications in observation group was 14.7%, similar with 18.1% in the control group （P 〉 0.05） while the total effective rate was 85.3%, signi？cantly higher than 66.7% in control group （P 〈 0.05）. After the treatment, in the observation group, the levels of CD3＋, CD4＋, IgG, IgA and IgM were （50.58±9.15）%, （36.23±5.24）%, （15.56±1.95） g/L, （2.45±0.45） g/L and （2.54±0.51） g/L, respectively, significantly higher than those in control group. Also in observation group, the levels of AFP, CEA, CA-125 and AFU were （20.12±2.34） μg/L, （10.97±1.36） μg/L, （24.56±2.19） U/mL and （23.45±2.98） g/L, respectively, signi？cantly lower than those in control group. Conclusion Shenyi Capsule combined with laparoscopic anatomical segmentectomy in thetreatment of elderly liver cancer plays an effective role and can improve the immune functions in the patients.
出处
《中国中西医结合外科杂志》
CAS
2018年第1期21-26,共6页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
参-胶囊
腹腔镜解剖性肝段切除术
老年
原发性肝癌
Shenyi Capsule
laparoscopic anatomical segmentectomy
elderly
primary liver cancer
