摘要
目的探讨克银丸联合阿维A胶囊治疗银屑病的临床疗效。方法选取2016年2月—2017年2月在河南省职工医院诊治的银屑病患者78例,随机分为对照组(39例)和治疗组(39例)。对照组患者口服阿维A胶囊,10 mg/次,3次/d。治疗组在对照组的基础上口服克银丸,10 g/次,2次/d。两组患者均经过8周治疗。观察两组患者临床疗效,比较治疗前后两组患者银屑病面积与严重性指数(PASI)评分、血清学指标和脂代谢指标。结果治疗后,对照组的总有效率为74.36%,显著低于治疗组的92.31%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组PASI评分均明显降低(P<0.05);且治疗组PASI评分比对照组更低(P<0.05)。治疗后,两组血清白细胞介素-17(IL-17)、血管内皮生长因子(VEGF)、γ-干扰素(IFN-γ)、丙二醛(MDA)和脂质过氧化产物(LPO)水平均显著降低,同组比较差异具有统计学意义(P<0.05);且治疗组上述血清学指标显著低于对照组(P<0.05)。治疗后,两组患者血清高密度脂蛋白胆固醇(HDL-C)水平均明显升高(P<0.05);载脂蛋白A1(ApoA1)、低密度脂蛋白胆固醇(LDL-C)显著降低(P<0.05);且治疗组比对照组改善的更显著(P<0.05)。结论克银丸联合阿维A胶囊治疗银屑病可有效降低机体炎症反应,改善机体血脂代谢水平和氧化应激状态,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Keyin Pills combined with Acitretin Capsules in treatment of psoriasis. Methods Patients（78 cases） with psoriasis in Henan Staff Hospital from February 2016 to February 2017 were randomly divided into control（39 cases） and treatment（39 cases） groups. Patients in the control group were po administered with Acitretin Capsules, 10 mg/time, three times daily. Patients in the treatment group were po administered with Keyin Pills on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and PASI scores, serological indexes, and lipid metabolism indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 74.36%, which was significantly lower than 92.31% in the treatment group, and there were differences between two groups（P〈0.05）. After treatment, the PASI scores in two groups were significantly decreased（P〈0.05）. And the PASI scores in the treatment group were significantly lower than that in the control group（P〈0.05）. After treatment, IL-17, VEGF, and IFN-γ, MDA and LPO levels in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the serological indexes in the treatment group were significantly lower than those in the control group（P〈0.05）. After treatment, the HDL-C in two groups was significantly increased（P〈0.05）, but ApoA1 and LDL-C levels was significantly decreased（P〈0.05）. And the level of these indexes in the treatment group was significantly better than that in the control group（P〈0.05）. Conclusion Keyin Pills combined with Acitretin Capsules in treatment of psoriasis can effectively reduce inflammation, and improve the level of blood lipid metabolism and oxidative stress, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2018年第1期101-104,共4页
Drugs & Clinic
