摘要
目的:探讨三种方案联合鼻塞双水平正压通气治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法:纳入90例NRDS患儿,采用随机数字表法分为A组、B组和C组,每组30例,在鼻塞双水平正压通气基础上分别联用肺表面活性剂、大剂量氨溴索和肺表面活性剂+大剂量氨溴索,分析比较三组患儿临床疗效、血氧饱和度、呼吸频率、心率、住院时间、住院费用及并发症情况。结果:C组的总有效率显著高于A组(90.00%VS 76.67%)和B组(90.00%VS73.33%),差异均有统计学意义(P<0.05);治疗后1h、12h、24h,三组患儿的血氧饱和度均持续升高,呼吸频率和心率逐渐下降,且C组患儿改善幅度最大,与A组、B组比较差异均有统计学意义(P<0.05);C组患儿住院时间明显短于A组(15.13±2.64VS 24.05±3.89)和B组(15.13±2.64VS 28.91±4.06),差异均有统计学意义(P<0.05);C组并发症发生率显著低于A组(13.33%VS 33.33%)和B组(13.33%VS 30.00%),差异均有统计学意义(P<0.05)。结论:鼻塞双水平正压通气联用肺表面活性剂+大剂量氨溴索治疗NRDS患儿成效显著,能迅速改善患儿症状,降低并发症发生率,值得临床推广应用。
Objective:This study was aimed to investigate the efficacy of the three programs combined with nasal BiPAP treatment of neonatal respiratory distress syndrome(NRDS).Methods:Selected November 2015 to November2016 admitted to our hospital NRDS 90 cases,according to the table of random numbers divided into Group A(lung surfactant),Group B(high dose ambroxol cable)and group C(lung surfactant+ambroxol)30 cases,the clinical efficacy of the three groups,blood oxygen saturation,respiratory rate,heart rate,length of stay,hospital costs and adverse reactions.Results:The effective rate of C group was significantly higher than A group(90.00% VS 76.67%)and B group(90.00% VS 73.33%)(P<0.05).1 h,12 h,24 h,three sets of oxygen saturation in children continues to rise after the treatment,and respiratory rates and heart rates decreased;and compared with group A and B,C group had the greater degree of improvement.Hospitalization of children in group C was significantly lower than that of group A(15.13±2.64 VS 24.05±3.89),and group B(15.13±2.64 VS 28.91±4.06),the difference was statistically significant(P<0.05).The adverse event rate of C group was significantly lower than that of group A(13.33 % VS33.33%)and group B(13.33% VS 30.00%),and the difference was statistically significant(P<0.05).Conclusion:On the basis of nasal BiPAP on pulmonary surfactant combined with high dose ambroxol solution treatment of NRDS with remarkable results can quickly correct hypoxia in children,with lower adverse event,which is helpful for clinical practice.
出处
《医学理论与实践》
2018年第4期484-486,共3页
The Journal of Medical Theory and Practice
