摘要
结肠癌相关转录因子1(CCAT1)是结直肠癌组织中新近发现的一种异常高表达的长链非编码RNA(lncRNA),具有促进肿瘤细胞增殖及侵袭转移等作用。CCAT1通过内源竞争等机制与微小RNA(miRNA)或蛋白相互作用参与调控机体的诸多生理病理过程,尤其是消化道肿瘤的形成与发展,它有望成为有价值的肿瘤标志物和治疗靶点。
Colon cancer associated transcript 1（ CCAT1） is a kind of long non-coding RNA（ lncRNA） found recently,which is aberrant overexpression in colorectal cancer,and it can promote cancer cell proliferation,invasion and metastasis. CCAT1 involves in the regulation of multiple pathophysiological processes,especially the formation and progression of gastrointestinal cancer,through the interaction with microRNA（ miRNA） or protein by regulation mechanism like endogenous competition,and it is expected to serve as a valuable biomarker and therapeutic target.
出处
《基础医学与临床》
CSCD
2018年第2期237-240,共4页
Basic and Clinical Medicine
基金
国家自然科学基金(81602088)
黑龙江省卫生计生委科研课题(2016-049)
黑龙江省博士后资助课题(LBHZ16096)
哈尔滨医科大学创新科学研究基金(2016LCZX09)
