摘要
目的探讨腹腔镜术后应用左炔诺孕酮宫内节育器(曼月乐)治疗子宫内膜异位症的临床疗效和安全性。方法选取沈阳军区总医院自2016年3月至2017年2月收治的72例子宫内膜异位症患者为研究对象,所有患者均行腹腔镜手术治疗,治疗后,采用随机数字表法将患者分为两组,激素组36例术后接受促性腺激素释放激素类似物治疗,曼月乐组36例术后接受子宫内植入曼月乐治疗。随访6、12个月,比较两组治疗前后月经周期、经期、经量、疼痛程度、有效率、不良反应发生率及复发率。结果治疗后6个月,激素组和曼月乐组患者的月经周期均较治疗前延长,激素组患者的经期较治疗前缩短(P<0.05)。治疗后12个月,曼月乐组患者的月经周期较治疗前延长,曼月乐组患者的经期较治疗前缩短(P<0.05);曼月乐组患者的月经周期较激素组延长,曼月乐组患者的经期较激素组缩短(P<0.05)。治疗后6、12个月,激素组和曼月乐组患者的经量均较治疗前减少(P<0.05);治疗后12个月,曼月乐组患者的经量降低幅度明显大于激素组(P<0.05)。治疗后6、12个月,激素组和曼月乐组患者的疼痛程度均较治疗前减轻(P<0.05);治疗后12个月,曼月乐组患者的疼痛程度轻于激素组(P<0.05)。曼月乐组有效率高于激素组,不良反应发生率和复发率均低于激素组(P<0.05)。结论子宫内膜异位症患者腹腔镜术后植入曼月乐可明显提高疗效,减轻症状,减少不良反应和复发,改善预后。
Objective To investigate the efficacy and safety of Levonorgestrel Intrauterine System in the treatment of endometriosis after laparoscopy. Methods A retrospective study was performed on 72 cases of patients with endometriosis who were admitted from March 2016 to February 2017. All the patients were performed laparoscopic surgery,after treatment,all the patients were randomly divided into the hormone group and the Mirena group,with 36 cases in each group. Patients in the hormone group were postoperatively treated with gonadotropin-releasing hormone analogue; the others in the Mirena group were postoperatively implanted Levonorgestrel Intrauterine System in uterus. Follow up was performed at 6 and 12 months after surgery,the menstrual cycle,menstrual period,menstrual blood volume,pain degree,effective rate,adverse reactions and recurrence rate were compared between the two groups. Results Six months after treatment,the menstrual cycle in both groups were longer than those before the treatment,the menstrual period in the hormone group was shorter than that before the treatment,and the difference was statistically significant（ P〈0. 05）. Twelve months after treatment,the the menstrual cycle in the Mirena group was longer than that before the treatment,the menstrual period was shorter than that before the treatment（ P〈0. 05）; the menstrual period in the Mirena group was longer than that in the hormone group,and the menstrual period was shorter than that in the hormone group（ P〈0. 05）. Six and twelve months after treatment,the menstrual blood volume in both groups were less than those before treatment（ P〈0. 05）; twelve months after treatment,the menstrual bold volume in the Mirena group was significantly lower than that in the hormone group（ P〈0. 05）. Six and twelve months after treatment,the pain degree was lower than those before the treatment in both groups（ P〈0. 05）; twelve months after treatment,the pain degree in the Mirena group was less than that in the hormone group（ P〈0. 05）. The effective rate in the Mirena group was higher than that in the hormone group,the adverse reactions and recurrence rate were lower than those in the hormone group,and the differences were statistically significant（ P〈0. 05）. Conclusion Mirena can significantly improve the effective rate,reduce the clinical symptoms with less adverse reactions and recurrence rate,thus improve the prognosis of patients with endometriosis after laparoscopic surgery.
出处
《临床军医杂志》
CAS
2018年第2期159-162,共4页
Clinical Journal of Medical Officers
基金
辽宁省自然科学基金(2015020719)
