摘要
目的探讨慢性心力衰竭患者应用阿托伐他汀钙治疗的血浆内皮素及心功能的变化。方法选取我院接诊的100例慢性心力衰竭患者,按照随机数字表法分为观察组和对照组,各50例。观察组给予阿托伐他汀钙治疗,对照组给予常规药物治疗。观察两组患者治疗前、后血浆内皮素血脂及心功能的变化。结果观察组的心功能改善总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者的ET-1、HDL-C、TC、LDL-C指标比较,差异均无统计学意义(P>0.05);治疗后,两组患者的ET-1、HDL-C、TC、LDL-C指标均改善,且观察组优于对照组(P<0.05)。结论在慢性心力衰竭患者的治疗过程中采用阿托伐他汀钙治疗,能够优化患者的血浆内皮素指标,改善患者的心功能状况。
Objective To investigate the changes of plasma endothelin and cardiac function in patients with chronic heart failure（CHF） treated with atorvastatin calcium. Methods A total of 100 patients with CHF in our hospital were enrolled and divided into observation group and control group according to the random number table method, with 50 cases in each group.The observation group received atorvastatin calcium treatment, the control group was given conventional drug therapy. The changes of plasma endothelin and cardiac function of the two groups were observed before and after treatment. Results The total effective rate of heart function improvement in the observation group was higher than that in the control group（P〈0.05）.Before treatment, there were no significant differences in ET-1, HDL-C, TC and LDL-C between the two groups（P〈0.05）;after treatment, the indexes of ET-1, HDL-C, TC, LDL-C in both groups improved, and those of the observation group were better than the control group（P〈0.05）. Conclusion In the treatment of patients with CHF, the use of atorvastatin calcium can optimize patients＇ plasma endothelin indexes, improve the patients＇ cardiac function.
出处
《临床医学研究与实践》
2018年第4期27-28,共2页
Clinical Research and Practice
