摘要
目的评估中西医结合治疗急性肺损伤(ALI)的临床疗效。方法计算机检索中文数据库(中国知网、万方、维普、CBM)和外文数据库(Pub Med,Embase,Cochrane Library),查找中西医结合治疗ALI的随机对照临床试验,根据纳入排除标准进行筛选,确定纳入的文献,进行数据提取。采用Cochrane的偏倚风险表评估研究质量,使用Rev Man5.3.3进行统计分析。结果共纳入文献16篇,756例患者。Meta分析结果显示,与常规西医治疗组相比,中西医结合治疗组可降低ALI患者死亡率(RR=0.54,95%CI[0.34,0.87],P=0.01)、降低ARDS发生率(RR=0.41,95%CI[0.25,0.65],P=0.0002)及降低CRP浓度(SMD=-0.49,95%CI[-0.81,-0.17],P=0.002)。结论中西医结合在治疗ALI方面可能具有较好的临床疗效。但文献质量有待提高,故需要大量随机对照双盲试验来论证。
Objective： To assess the clinical effect of the combination of traditional Chinese medicine and Western medicine in acute lung injury. Methods： Randomized controlled trials related to the therapy for acute lung injury with the combination of traditional Chinese medicine and Western medicine were searched and selected from databases including CNKI,Wanfang Data,Weipu Data,CBM,Pub Med,Embase and Cochrane Library. All literature was screened according to the inclusion and exclusion criteria screening and data was extracted by excel software. The Cochrane risk of bias table was used to valuate the study quality,and Rev Man 5.3 was used for data analysis. Results： 16 RCTs,involving 756 patients,were included into the study. The Meta-analysis results showed that compared with Western medicine treatment,the combination of traditional Chinese medicine and Western medicine treatment could reduce the mortality risk（RR=0.54,95%CI [0.34,0.87],P = 0.01） and the incidence of ARDS（RR=0.41,95%CI [0.25,0.65],P = 0.0002） and decrease the concentration of CRP（SMD=-0.49,95% CI [-0.81,-0.17],P = 0.002）. Conclusion： The combination of traditional Chinese medicine and Western medicinemay has a better effect. However,due to the low methodology and quality and small sample size of included RCTs in this study,more RCTs with a larger sample size are required to further verify the efficacy and safety of the combination of traditional Chinese medicine and Western medicine therapy for ALI.
作者
刘巧
陈远彬
刘志平
罗力
林琳
LIU Qiao,CHEN Yuanbin,LIU Zhiping,et al.(The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangdong, Guangzhou 510405, China)
出处
《中国中医急症》
2018年第3期384-388,393,共6页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金项目(81503511)
广东省中医药局科研项目(20161146)
关键词
急性肺损伤
中西医结合
随机对照试验
META分析
Acute lung injury
Combination of traditional Chinese medicine and Western medicine
Randomized controlled trials
Meta-analysis
