摘要
目的:探讨使用他汀类药物后疲乏(他汀源性疲乏)的发生情况及相关影响因素。方法:随访观察474例患者服用他汀类药物1个月及3个月时疲乏的发生率,分析不同因素对疲乏发生率的影响。结果:服用他汀类药物1个月时疲乏的发生率为12.9%,3个月时为14.6%,不同服药时间的疲乏发生率无显著差异。疲乏人群低密度脂蛋白胆固醇(LDL-C)水平与无疲乏人群相比无显著性差异。随访1个月时,女性、合用β阻滞剂、糖尿病和心功能不全人群中他汀源性疲乏明显增加。随访3个月时女性、高龄、糖尿病和心功能不全人群中他汀源性疲乏明显增加。多因素回归分析显示,女性、糖尿病及心功能不全明显增加了他汀源性疲乏的发生。服用辅酶Q10可以部分(但非全部)缓解他汀源性疲乏。结论:女性、糖尿病及心功能不全患者他汀源性疲乏的发生率明显增加。
Objective：This clinical study will aim to assess incidence and influence factors of statins induced fa- tigue in patients taking statins. Method： A total of 474 subjects completed the study and the occurrence of fatigue was assessed after one-month and three-month follow up. Impacts of clinically relevant factors （sex, age, hypertension, diabetes, heart failure, renal function and LDL-C level） were evaluated via multivariate analysis. Result： （1）The incidence of statins induced fatigue was 12.9% at one-month follow up and 14.6 % at three-month follow up. （2）The LDL-C level in patients suffering fatigue was not statistically different from that in non-fatigue patients （P〉0.05）. （3）The incidence of statins induced fatigue was significantly greater in female patients or in patients with diabetes, combined with beta blocker or heart failure at the one-month follow-up and was significantly greater in female or older patients or in patients with diabetes or heart failure at the three-month follow-up. （4）Logistic multi-factor regression analysis showed that female, diabetes and heart failure were the independent factors influencing the occurrence of statins induced fatigue. （5）Coenzyme Q10 alleviated the fatigue in some but not all patients. Conelusion：Being female, combined with beta blocker, diabetes and heart failure can increase the incidence of statins induced fatigue during follow-up period among patients taking statins.
作者
钟丽贞
胡高频
李传荣
孙飞
ZHONG Lizhen ,HU Gaopin, LI Chuanrong, SUN Fei(Department of Cardiology, the 210th Hospital of People＇s Liberation Army, Dalian,116021, Chin)
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2018年第3期263-266,共4页
Journal of Clinical Cardiology
