摘要
目的探讨微波消融术联合索拉非尼治疗原发性肝癌的临床效果。方法选取90例原发性肝癌患者的临床资料进行回顾性研究。根据不同治疗方法将所有患者分为观察组和对照组,每组45例。对照组采用经皮微波消融术治疗,观察组采用微波消融术联合索拉非尼治疗。比较2组患者的近期疗效、KPS评分、血清VEGF、bFGF水平、生存情况及不良反应发生率。结果观察组的有效率和疾病控制率(73.3%,91.1%)显著高于对照组(46.7%,62.2%)(P<0.05)。治疗后,观察组KPS评分显著高于对照组(P<0.05)。观察组血清VEGF、bFGF水平显著低于对照组(P<0.05)。观察组的中位无进展生存期、中位生存期及1年生存率均显著高于对照组,1年复发率显著低于对照组(P<0.05)。观察组各不良反应发生率均显著低于对照组(P<0.05)。结论微波消融术联合索拉非尼治疗原发性肝癌近期疗效较好,可改善患者生活质量,延长生存期。
Objective To evaluate the effect of microwave ablation combined with sorafenib in the treatment of primary liver cancer. Methods The clinical data of 90 patients with primary liver cancer were retrospectively studied. All patients were divided into the observation group and control group according to different treatment methods. The control group was treated by percutaneous microwave ablation, and the observation group was treated with microwave ablation combined with sorafenib. The short-term curative effect, KPS score, serum VEGF, bFGF level, survival rate and adverse reaction rate were compared between the 2 groups. Results The effective rate and disease control rate of the observation group （73.3 % ,91.1% ） were significantly high- er than that of the control group（46.7% ,62.2% ） （P 〈 0.05 ）. After treatment ,the KPS score in the observation group was signif- icantly higher than that of the control group （ P 〈 0.05 ）. The serum levels of VEGF and bFGF in the observation group were sig- nificantly lower than those of the control group （ P 〈 0.05 ）. The median survival time, median survival and 1 year survival rate were significantly higher in the observation group than in the control group, and the recurrence rate was significantly lower than that of the control group （ P 〈 0.05 ）. The incidence of adverse reactions in the observation group was significantly lower than that of the control group （ P 〈 0.05 ）. Conclusion The microwave ablation combined with sorafenib is effective in the treatment of pri- mary liver cancer, it can improve the quality of life and prolong the survival time.
作者
孙晓
徐恩松
邱春玉
董阳
SUN Xiao,XU Ensong, QIU Chunyu, et al.(Nanyang Central Hospital Tumor Hospital, Nanyang,47300)
出处
《实用癌症杂志》
2018年第4期664-667,共4页
The Practical Journal of Cancer
关键词
微波消融术
索拉非尼
原发性肝癌
效果观察
Microwave ablation
Sola Fini
Primary liver cancer
Effect observation
