摘要
目的探讨丁苯酞氯化钠注射液对急性脑梗死患者神经功能、日常生活能力及血管内皮功能的影响。方法选取146例急性脑梗死患者,采用随机数字表分为2组,对照组(n=73)采取常规治疗,研究组(n=73)在对照组的基础上加用丁苯酞氯化钠注射液,2组均治疗14 d为1个疗程,观察2组临床疗效。治疗前后评估2组神经功能缺损(NIHSS评分)及日常生活能力(ADL评分)情况,并对2组血管内皮功能[内皮素-1(ET-1)、一氧化氮(NO)]进行检测。结果观察组临床疗效明显优于对照组,差异有统计学意义(χ2=7.69,P<0.05)。治疗前2组NIHSS评分与ADL评分及ET-1与NO含量比较,差异无统计学意义(P>0.05);治疗14 d后,观察组NIHSS评分明显较对照组低,ADL评分较对照组高;观察组NO水平高于对照组,ET-1水平低于对照组,差异均有统计学意义(P<0.05)。结论丁苯酞氯化钠注射液治疗急性脑梗死,能够有效改善患者的内皮功能及神经功能缺损症状,提高日常生活活动能力,疗效显著,值得临床推广。
Objective To explore the effects of butylphthalide and sodium chloride injection on neurological function, daily living ability and vascular endothelial function in patients with acute cerebral infarction. Methods A total of 146 patients with a- cute cerebral infarction were studied and were randomly divided into two groups. The control group （n =73） received routine treat- ment. The study group （n = 73） was treated with butylphthalide and sodium chloride injection on the basis of the control group. Patients in the two groups were treated for 14 days a course and the clinical efficacy of two groups were observed. The neurological deficits （NIHSS scores） and activities of daily living （ADL scores） were assessed before and after treatment in the two groups. The vascular endothelial functions between the two groups were detected, such as endothelin-1 （ET-1） and nitric oxide （NO）. Resuits The clinical efficacy of the observation group was obviously better than that of the control group,the difference was statisti cally significant （x2 = 7.69, P〈0.05）. Before treatment, there were no significant differences on NIHSS score and ADL score, ET- 1 and NO contents between the two groups （P〉0.05）. After treatment of 14 days, NIHSS score of the observation group was significantly lower than that of the control group, and ADL score was higher than that of the control group; the level of NO in the observation group was higher than that of the control group, and the level of ET-1 was lower than that of the control group, the differences were statistically significant （P〈0.05）. Conclusion Butylphthalide and sodium chloride inieetion in the treatment of acute cerebral infarction can effectively improve the endothelial function and neurological impairment symptoms, and improve the activities of daily living. The effect is remarkable. It is worthy of clinical promotion.
作者
张贇
卢仁凯
聂方华
郭志松
曾西
ZHANG Yun1 ,LU Renkai1 ,NIE Fanghua1 ,GUO Zhisong2 ,ZENG Xi2(1）Department of Neurology,People＇s Hospital of Taikang County , Taikang 461400,China ;2） ICU of Henan Province People＇s Hospital ,Zhengzhou 450003 ,China ; 3） Department of Rehabilitation, the First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2018年第4期420-423,共4页
Chinese Journal of Practical Nervous Diseases
基金
河南省教育厅科技攻关项目(14A320024)
关键词
急性脑梗死
丁苯酞氯化钠注射液
内皮功能
神经功能
日常生活能力
Acute cerebral infarction
Butylphthalide and sodium chloride injection
Endothelial function
Neurological func- tiom Daily living ability
