摘要
第二代药物洗脱支架作为异物,对血管壁有长期炎症反应,这是导致支架术后远期血栓形成和支架内再狭窄的重要诱因。而生物可降解支架能克服这一缺陷。目前,生物可降解支架材料选择分为高分子聚合物材料和合金材料。在可降解高分子材料中,聚乳酸和其改性共聚物备受关注。聚乳酸是一种具有良好生物相容性和可降解性能的高分子材料,在血管支架的制备中具有广泛运用。聚乳酸既是一种很优秀的支架药物涂层的载体,也可以被开发作为支架骨架结构。
The second-generation drug-eluting stents, as foreign bodies, have long-term inflammatory response to the vessel wall, which is an important cause of long-term thrombosis and in-stent restenosis after stenting. Biodegradable stents can overcome this drawback. At present, the biodegradable scaffold material is divided into polymer materials and alloy materials. Among biodegradable polymers, polylactic acid and its modified copolymers attract much attention. Polylactic acid is a kind of polymer material with good biocompatibility and biodegradability. It is widely used in the preparation of vascular stents. Polylactic acid is both a good carrier for stent drug coatings and can also be developed as a scaffold framework.
作者
朱月琳
汤文浩
胡双龙
赵杰
周敏
李晓强
ZhuYuelin1, Tang Wenhao1, Zhou Min2 ,Hu Shuanglong2, Zhao Jie2(1 School of Medicine, Southeast University, Nanjing 210009, China; 2 Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Chin)
出处
《血管与腔内血管外科杂志》
2017年第5期968-971,976,共5页
Journal of Vascular and Endovascular Surgery
关键词
生物可降解
聚乳酸
血管支架
biodegradable
polylactic acid
vascular stent.
