摘要
目的：探讨化瘀除湿通痹方对肾虚血瘀型膝骨关节炎（knee osteoarthritis,KOA）患者的疗效观察及对关节液中炎症因子及氧化应激因子的影响。方法：选取2016年1月—2016年12月丹东市中医院收治的172例肾虚血瘀型KOA患者作为研究对象,根据随机、对照、双盲原则,将患者随机分为对照组（86例）和观察组（86例）,对照组予以盐酸氨基酸葡萄糖胶囊口服,观察组在对照组基础上加以化瘀除湿通痹方治疗,两组患者的疗程均为12周。分别采用膝关节骨关节炎指数（WOMAC指数）、Lyshom膝部评分量表、视觉疼痛模拟评分（VAS评分）评价两组患者治疗前后的关节症状严重程度、膝部功能改善情况、关节疼痛变化情况。同时检测两组患者治疗前后关节液炎症指标、氧化应激指标变化情况,并比较两组患者的临床疗效。结果：治疗后,对照组及观察组的WOMAC指数、VAS评分、IL-1β、TNF-α、IL-6、MDA水平均显著低于治疗前,且观察组显著低于对照组;Lyshom评分、SOD水平均显著高于治疗前,且观察组显著高于对照组,均P〈0.05;对照组的总有效率为76.74%,观察组的总有效率为93.02%,经Z检验,观察组的总有效率显著高于对照组,P〈0.05。结论：在肾虚血瘀型膝骨关节炎患者中采用化瘀除湿通痹方治疗,能有效改善患者的膝关节功能,提高临床疗效,这可能与其减少关节液中炎症因子的表达以及抑制氧化应激有关。
Objective：To investigate the effect of Huayu Chushi Tongbi Decoction on knee osteoarthritis（KOA）and its influence on inflammatory factors and oxidative stress factors in synovial fluid. Methods：172 cases of kidney deficiency and blood stasis in patients with KOA from January 2016 to December 2016 in Dandong hospital of traditional Chinese medicine were as the research objects,according to a randomized,controlled,double-blind principle,patients were randomly divided into control group（86 cases）and observation group（86 cases）,the control group was given oral glucose amino acid hydrochloride capsules,the observation group was given on the basis of the control group,two groups of patients were treated for 12 weeks. Respectively with knee osteoarthritis index（WOMAC index）,Lyshom knee score,visual analogue score（VAS score）to evaluate the severity of symptoms before and after treatment in two groups knee joint function evaluation,the changes of joint pain. At the same time,two groups of patients were examined before and after treatment of joint fluid inflammation index,oxidative stress index changes,and compared the clinical efficacy of the two groups. Results：After the treatment,the control group and the observation group,WOMAC index,VAS score,IL-1β,TNF-α,IL-6,MDA levels were significantly lower than before treatment,and the observation group was significantly lower than the control group;Lyshom score,SOD levels were significantly higher than that before treatment,and the observation group were significantly higher than the control group,P〈0.05;the total effective rate of control group was 76.74%,the total effective rate of observation group was 93.02%,by Z test,the total efficiency of the observation group was significantly higher than the control group,P〈0.05. Conclusion：Treating knee osteoarthritis patients with kidney deficiency and blood stasis with Huayu Chushi TongbiDecoction,can effectively improve the knee joint function of patients,improve the clinical curative effect,which may be related to decrease the expression of inflammatory cytokines in synovial fluid and inhibition of oxidative stress.
作者
吕颖智
LYU Yingzhi(Dandong Hospital of Traditional Chinese Medicine, Dandong 118000, Liaoining, China)
出处
《辽宁中医药大学学报》
CAS
2018年第3期205-208,共4页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
氧化应激
炎症因子
肾虚血瘀型
膝骨关节炎
化瘀除湿通痹方
oxidative stress
inflammatory factors
kidney deficiency and blood stasis
knee osteoarthritis
Huayu Chushi Tongbi Decoction
