摘要
目的观察氧气驱动雾化吸入在支气管哮喘急性发作救治中的临床效果。方法选取96例支气管哮喘急性发作患者作为研究对象，采用随机数字表法分为观察组和对照组，各48例。两组患者均采用沙丁胺醇和布地奈德雾化吸入治疗，其中对照组患者采用超声雾化吸入法，观察组患者采用氧气驱动雾化吸入法。观察两组治疗前后的血氧饱和度（SpO2）、最大呼气峰流速（PEF）、第1秒用力呼气容量（FEV1）和呼吸指数（RI），比较主要临床症状消失时间，分析其临床效果。结果治疗后，观察组的总有效率91．67％，对照组的总有效率为72．92％，组间差异有统计学意义（χ^2=7．19，P〈0．05）。与对照组相比，观察组的发热、咳嗽、气喘、哮鸣音、肺部啰音及气短等主要临床症状消失时间均明显缩短[观察组：（3．05±1．23）d、（4．43±1．16）d、（3．12±1．11）d、（4．26±1．37）d、（4．98±1．75）d、（3．51±1．37）d，对照组：（4．14±1．03）d、（7．75±1．98）d、（5．75±1．86）d、（6．53±1．46）d、（8．42±1．55）d、（6．53±1．46）d]，差异均有统计学意义（t=4．71、10．02、8．41、7．86、10．20、10．45，均P〈0．01）。治疗后，两组SpO2、PEF、FEV1均明显升高[观察组：（98．70±1．44）％、（126．33±9．87）mL／min、（2．06±0．52）L；对照组：（83．15±1．39）％、（108．32±7．26）mL／min、（1．42±0．38）L]，而RI显著下降（观察组：0．17±0．08，对照组：0．27±0．06），两组差异均有统计学意义（t观=36．18、16．77、12．04、10．69，t对=11．03、8．15、5．34、2．69，均P〈0．01），且观察组的SpO2、PEF、FEV1及RI改善程度明显优于对照组（t=53．83、10．18、6．88、6．74，均P〈0．01）。结论在救治支气管哮喘急性发作中，采用氧气驱动雾化吸人治疗临床疗效显著，可有效地缓解患者发热、咳嗽等主要的临床症状，改善肺通气功能，值得临床进一步推广应用。
Objective To analyze the effect of oxygen driven aerosol inhalation in the treatment of acute exacerbation of bronchial asthma. Methods 96 patients with acute exacerbation of bronchial asthmawere selected as the subjects. They were divided into observation group and control group by the random number table ,48 cases in each group. All patients were treated with salbutamol and budesonide inhalation therapy, the control group was treated with ultrasonic atomization inhalation, the observation group was treated with oxygen driven aerosol inhalation. The changes of blood oxygen saturation（ SpO2 ） , maximum expiratory peak flow（ PEF）, forced expiratory volume in the first second （ FEV1 ） and respiratory index（RI） were observed before and after treatment in the two groups. The time of disappearance of major clinical symptoms was compared, and the clinical treatment effect was analyzed. Results After treatment,the total effective rate of the observation group was 91.67% ,which of the control group was 72.92% ,the difference between the two groups was statistically significant（ χ^2 = 7.19 ,P 〈 0.05 ）. Compared with the control group, the fever, cough, asthma, wheezing, shortness of breath, pulmonary rales and main clinical symptoms disappear time of-the observation group were significantly shortened [ observation group ： （ 3.05 ± 1.23 ） d, （ 4.43 ± 1. 16 ） d, （ 3. 12 ± 1.11）d,（4.26 ± 1.37）d, （4.98 ± 1.75） d, （3.51 ± 1.37）d;control group： （4.14 ± 1.03）d, （7.75 ± 1.98）d, （5.75 ± 1.86）d,（6.53 ± 1.46）d,（8.42 ± 1.55）d,（6.53 ± 1.46）d,t =4.71,10.02,8.41,7.86,10.20,10.45, all P 〈0.01 ]. After treatment, the SpO2, PEF and FEV1 of the two groups were significantly increased [ observation group ： （ 98.70 ± 1.44 ） %, （ 126.33 ± 9.87 ） mL/min, （ 2.06 ± 0. 52） L; control group： （ 83. 15 ± 1.39 ） %,（ 108.32 ± 7.26） mL/min, （ 1.42 ± 0.38 ） L ], while RI decreased significantly [ observation group ： （ 0.17 ± 0.08 ）, control group： （0.27 ± 0.06）, the differences were significant （to = 36.18,16.77,12.04,10.69, te = 11. 03,8.15, 5.34,2.69, all P 〈 0. 01 ）, and the improvement of SpO2 ,PEF, FEV1 and RI of the observation group were significantly better than those of the control group（t = 53.83 10.18,6.88,6.74, all P 〈 0. 01 ）. Conclusion In the treatment of acute exacerbation of bronchial asthma, the clinical efficacy of oxygen driven aerosol inhalation is significant. The way can better alleviate patients＇ major chnical symptoms, such as fever, cough, improve lung ventilation function, and is worthy of further clinical application.
作者
沈剑杰
曹冬敏
Shen Jianjie , Cao Dongmin.(Department of Emergency, the First People＇s Hospital of Tongxiang , Tongxiang , Zhejiang 314500, Chin)
出处
《中国基层医药》
CAS
2018年第8期1014-1018,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
投药
吸入
哮喘
Administration,inhalation
Asthma
