摘要
目的探讨肿瘤异常蛋白结合Ki-67检测评估非小细胞肺癌(NSCLC)患者生存状况的价值。方法选取2010年2月至2012年1月间山东省潍坊市昌乐县人民医院收治的110例NSCLC患者,依据患者生存时间分为A组(≥5年)41例与B组(<5年)69例。检测所有患者肿瘤组织中Ki-67蛋白及肿瘤异常蛋白的表达,比较两组患者肿瘤组织中Ki-67结合肿瘤异常蛋白的差异。结果肿瘤的分化程度、病理类型、吸烟史及TNM分期对NSCLC患者的生存时间影响不大,差异均无统计学意义(均P>0.05);年龄及性别对NSCLC患者的生存时间有很大的影响,差异均有统计学意义(均P<0.05)。肿瘤异常蛋白阳性率高及Ki-67增殖指数高的NSCLC患者的生存时间均会明显缩短,差异均有统计学意义(均P<0.05)。A组患者肿瘤异常蛋白和Ki-67检测均阳性的例数均少于B组,A组患者肿瘤异常蛋白和Ki-67检测均阴性的例数明显多于B组,差异均有统计学意义(均P<0.05)。结论肿瘤异常蛋白结合Ki-67检测,能更好地预测NSCLC患者的生存状况。
Objective To explore the significance of tumor abnormal protein combined with ki-67 in the assessment of of survival in patients with non-small cell lung cancer（NSCLC）. Methods A total of110 patients with NSCLC were selected at Changle County People＇s Hospital from February 2010 to January2012. According to survival time,the patients were divided into 2 groups： group A（survival≥5 years,41 patients） and group B（survival 5 years,69 patients）. The expression of the Ki-67 and the abnormal protein in tumor tissues were detected in the patients. The differences in ki-67 combined with tumor abnormal protein between the two groups were compared. Results The degree of differentiation of tumor,pathological type,smoking history and the TNM staging had little effect on survival in NSCLC patients（P〈0. 05）.Age and gender had a significant impact on the survival time（all P〈0. 05）. The survival time was significantly shortened in NSCLC patients with high abnormal protein positive rate and Ki-67 index（all P〈0. 05）. The number of patients with positive abnormal tumor protein and Ki-67 were significantly lower in group A than in group B. The number of patients with negative abnormal tumor protein and Ki-67 were significantly higher in group A than in group B. Conclusion The combination of abnormal tumor protein and ki-67 test can better predict the survival of the patients with non-small cell lung cancer.
作者
刘善利
刘斌
高晓慧
崔伟华
李宁
秦宇杰
LIU Shan-li, LIU Bin, GAO Xiao-hui, CUI Wei-hua, LI Ning, Q1N Yu-fie(Medical Clinical Laboratory, Changle County People＇s Hospital,Weifang 262400, Chin)
出处
《中国肿瘤临床与康复》
2018年第3期292-294,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
潍坊市科技发展计划项目(2016yx144)
关键词
肿瘤异常蛋白
KI-67
癌
非小细胞肺
生存状况
Tumor abnormal protein
Ki-67
Carcinoma, non-small cell lung
Living conditions
