摘要
目的比较地诺前列酮栓和缩"素用于瘢痕子宫妊娠阴道试产的催产效果和安全性评价,为瘢痕子宫妊娠产妇药物催产方案的选择提供参考。方法选取2015-2016年任丘市中医院妇产科收治的144例符合阴道试产条件的瘢痕子宫再次妊娠产妇随机分为对照组、地诺前列酮组和缩宫素组各48例,地诺前列酮组产妇阴道放置地诺前列酮栓,缩宫素组产妇静脉滴注缩宫素,对照组自然分娩,比较3组产妇宫颈成熟情况、产程、分娩方式、母婴预后。结果 (1)用药后4、8、12和24 h时3组产妇Bishop评分差异有统计学意义(P<0.05),并且地诺前列酮组Bishop评分高于缩宫素组,差异有统计学意义(P<0.05)。(2)3组产妇临产时间、总产程和阴道产率差异有统计学意义(P<0.05),并且地诺前列酮组产妇诱发临产时间和总产程均较缩宫素组显著降低,差异有统计学意义(P<0.05),而地诺前列酮组和缩宫素组产妇的分娩方式差异无统计学意义(P>0.05)。(3)3组产妇产后并发症总发生率差异有统计学意义(P<0.05),但是地诺前列酮组和缩宫素组产妇并发症总发生率差异无统计学意义(P>0.05)。(4)3组新生儿并发症总发生率差异有统计学意义(P<0.05),但是地诺前列酮组和缩宫素组新生儿并发症总发生率差异无统计学意义(P>0.05)。结论地诺前列酮和缩宫素均可以促进瘢痕子宫妊娠产妇宫颈成熟,降低瘢痕子宫妊娠产妇的剖宫产率,两组妊娠结果差异无统计学意义(P>0.05),但是地诺前列酮栓可显著缩短产妇总产程。
Objective To compare the effects of dinoprostone suppositories and oxytocin in labor augmen during vaginal trial production of patients with cesarean scar pregnancy （CSP） and safety evaluation, provide a reference for choice of drugs for labor augmen in CSP pa- tients. Methods A total of 144 patients with CSP meeting the criteria of vaginal trial production were selected from Department of Gynecolo- gy and Obstetrics in Renqiu Municipal Hospital of Traditional Chinese Medicine from 2015 to 2016, then they were randomly divided into control group, dinoprostone group, and oxytocin group, 48 patients in each group. The patients in dinoprostone group were treated by dinopr- oxone suppositories in vagina, the patients in oxytocin group were treated by intravenous drip of oxytocin, and the patients in control group were gave natural childbirth. The degrees of cervical maturation, labor stages, delivery modes, prognosis of mothers and infants in the three groups were compared. Results At 4, 8, 12, and 24 hours after treatment, there were statistically significant differences in Bishop score a- mong the three groups （ P〈0. 05） , Bishop scores in diuoprostone group were statistically significantly higher than those in oxytocin group （P〈0. 05） . There were statistically significant differences in labor time, the time of total stages of labor, and vaginal delivery rate among the three groups （P〈0. 05）, labor time and the time of total stages of labor in dinoprostone group were statistically significantly lower than those in oxytocin group （ P〈0. 05 ） , but there was no statistically significant difference in delivery modes between dinoprostone group and oxytocin group （P〉0. 05 ） . There was statistically significant difference in the total incidence rate of postpartum complications among the three groups （P〈0. 05）, but there was no statistically significant difference in the total incidence rate of postpartum complications between dinoprostone group and oxytocin group （P〉0.05） . There was statistically significant difference in the incidence rate of neonatal complications among the three groups （ P〈0. 05 ）, but there was no statistically significant difference in the incidence rate of neonatal complications between dinoprostone group and oxytocin group （P〉0. 05） . Conclusion Both dinoprostone and oxytocin can promote cervical maturation and reduce the rate of cesarean section of CSP patients. There was no statistically significant difference in pregnancy outcomes between dinoprostone group and oxytocin group （P〉0. 05）, but dinoprostone suppositories can significantly shorten the total stages of labor.
作者
蒋秀娟
边小松
JIANG Xiu-Juan, BIAN Xiao-Song.(Department of Gynecology and Obstetrics, Renqiu Municipal Hospital of Traditional Chinese Medicine, Renqiu, Hebei 062500, Chin)
出处
《中国妇幼保健》
CAS
2018年第7期1489-1492,共4页
Maternal and Child Health Care of China
关键词
瘢痕子宫妊娠
地诺前列酮栓
缩宮素
催产效果
安全性
Cesarean scar pregnancy
Dinoprostone suppository
Oxytocin
Effect of labor augmen
Safety
