摘要
目的:研究宽筋藤醇提物对弗氏完全佐剂(CFA)诱导的佐剂性关节炎(AA)大鼠的影响。方法:除正常组外,其余各组大鼠足跖皮内注射CFA致AA大鼠模型,将模型大鼠随机分成模型组、宽筋藤高剂量组、宽筋藤中剂量组、宽筋藤低剂量组、甲氨蝶呤组,灌胃给药20 d后,进行全身及关节炎指数评分以及足爪肿胀度和血清细胞炎性因子的测定。结果:与模型组比较,宽筋藤醇提物能抑制AA大鼠关节肿胀程度,降低全身及关节炎指数评分和血清中白细胞介素-6(IL-6)、细胞肿瘤因子-α(TNF-α)、白细胞介素-1β(IL-1β)的水平。结论:宽筋藤醇提物能拮抗AA大鼠病情发展,其机制可能与其下调血清炎性因子IL-6、TNF-α、IL-1β的表达有关。
Objective： To investigate the preventive and therapeutic effects of the ethanol extracts from Chinese Tinospora （Tinosporae Sinensis Caulis） on rats with adjuvant arthritis （AA） which are induced by Freund＇s complete adjuvant（CFA）. Methods： Except for the normal control group, all rats were injected CFA through plantar subcutaneous injection to induce the AA. Rats with AA were randomly divided into five groups： model group, high-dose, middle-dose and low-dose of Chinese Tinospora （Tinosporae Sinensis Caulis）, and Methotrexate group. The rats in each group were respectively treated with corresponding medicine for 20 days. Arthritis was evaluated by whole body assessment and arthritis index, paws swelling and serum cell gene was determined. Results： The ethanol extracts from Chinese Tinospora （rrinosporae Sinensis Caulis） could inhibit secondary foot claw degree of swelling and reduce the score of whole body assessment and arthritis index and the levels of IL-6, TNF-α, and IL-1β as compared with the model group. Conclusion： The ethanol extracts from Chinese Tinospora （Tinosporae Sinensis Caulis） can inhibit the development of AA, and the mechanism may relate to inhibiting the expression of IL-6, TNF-α and IL-1β.
作者
吴凤荣
曾聪彦
戴卫波
高玉桥
钟希文
胡莹
WU Feng-rong;ZENG Cong-yan;DAI Wei-bo;GAO Yu-qiao;ZHONG Xi-wen;HU Ying(Zhongshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Zhongshan Guangdong 528400, Chin)
出处
《中医药导报》
2018年第7期37-39,47,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
广东省中山市科技计划资助项目(2014A1FC138)
