摘要
PI3K/Akt信号通路在多种细胞中活化,参与细胞的增殖、分化、凋亡、血管新生等病理、生理过程。血管的生成需要PI3K/Akt信号通路的激活,PI3K/Akt活化后可以广泛诱导鸡胚尿囊膜血管的生成。PI3K/Akt信号通路与其下游信号分子m TOR及多种促血管新生因子,如VEGF、HIF等相互作用,从而促进肿瘤血管新生。PI3K/Akt信号通路抑制剂能够抑制其血管新生作用,因此靶向PI3K/Akt信号通路为恶性肿瘤靶向治疗提供了新方法。
PI3 K/Akt signaling pathway is activated in variety of cells. It is involved in the pathological and physiological processes of cell proliferation,differentiation,apoptosis and angiogenesis. Angiogenesis is required for activation of the PI3 K/Akt signaling pathway,and activation of PI3 K/Akt induces extensive angiogenesis in chick embryo chorioallantoic membranes. The PI3 K/Akt signaling pathway interacts with its downstream signaling molecule m TOR and a variety of angiogenic factors such as VEGF and HIF,then enhancing tumor angiogenesis. Inhibitors of PI3 K/Akt signaling pathway can inhibit their angiogenesis,so targeting PI3 K/Akt signaling pathway provides a new approach for targeted therapy of malignant tumors.
作者
耿军辉
张丽军
王亚丽
付建珠
齐雪军
成志勇
张金金
Geng Junhui;Zhang Lijun;Wang Yali;Fu Jianzhu;Qi Xuejun;Cheng Zhiyong;ZhangJinjin(People＇s Hospital of Dingzhou , Hebei Dingzhou 073000, China;Chengde Medical University, Hebei Chengde 067000, China;The No. 1 Hospital of Baoding, Hebei Baoding 071000, China.)
出处
《现代肿瘤医学》
CAS
2018年第9期1462-1466,共5页
Journal of Modern Oncology
基金
河北省重点科技计划项目(编号:162777120D)
