摘要
目的分析生殖激素的比值在评估睾丸生精功能上的应用价值。方法回顾性分析308例在外院诊断为非梗阻性无精子症,睾丸病理为唯支持细胞综合征且来我院要求供精人工授精的临床资料。按照体外射出精液是否有精子,分为隐匿精子组和无精子组,比较两组间的生殖激素水平和遗传学指标差异,分析这些指标对评估唯支持细胞综合征患者的睾丸生精功能的价值。结果研究对象FSH/LH比值均值为2.4,其中隐匿精子组2.0,无精子组2.5,两者差异有统计学意义(P=0.001),而两组FSH、LH、PRL、T、FSH/T比值以及LH/T比值比较无显著差异。两组染色体和AZF基因比较有显著统计学差异(P<0.001)。结论 FSH/LH比值联合染色体和AZF基因等指标在评估唯支持细胞综合征患者的睾丸生精功能上比睾丸体积、精液量、精液PH值、FSH、LH、PRL、T、FSH/T比值以及LH/T比值更具有参考价值。
Objective To analyze the value of reproductive hormone ratio in assessing testicular spermatogenic function. Methods The clinical data of 308 patients who were diagnosed with non-obstructive azoospermia, Sertoli cellonly syndrome with testieular pathology outside the hospital, and required artificial insenfination with donor were analyzed retrospectively. According to whether there is sperm in vitro, they were divided into eryptozoospermie group and azoospermie group. We compared the differences in reproductive hormone levels and genetic indicators between the two groups, and analyzed the value of those indicators in testieular spermatogenie function of patients with Sertoli cell-only syndrome. Results The mean FSH/LH ratio of study population was 2.4, of which the value was 2. 0 among the eryptozoospernfie group was significantly lower than 2.5 in the azoospermie group （P = 0. 001 ）. However, there were no significant differences between the two groups in FSH, LH, PRL, T, FSH/T and LH/T ratio. The two groups differed significantly in chromosomal abnormality and AZF gene deletion （ P 〈 0. 001 ）. Conclusion Combined with chromosome and AZF gene, FSH/LH ratio has more reference value in the evaluation of testieular spermatogenie function of the patients with Sertoli cell-only syndrome, relative to indicators of testieular volume, semen volume, semen pH value, FSH, LH, PRL, T, FSH/T ratio and LH/T ratio.
作者
刘晃
刘兴章
郑厚斌
周雨
钟安
文任乾
唐运革
张欣宗
余森泉
LIU Huang;LIU Xingzhang;ZHENG Houbin;ZHOU Yu;ZHONG An;WEN Renqian;TANG Yunge;ZHANG Xinzong;YU Senquan(Guangdong Institute of family planning science and Technology, Key Laboratory of Male Reproduction and Genetics, National Health and Family Planning Commission of Chin)
出处
《中国生育健康杂志》
2018年第3期212-214,231,共4页
Chinese Journal of Reproductive Health
基金
广东省科技计划项目(2015A030313884)
广东省医学科研基金项目(B2018250)
关键词
生殖激素
隐匿精子症
生精功能
唯支持细胞综合征
reproductive hormone
ery-ptozoospermia
spermatogenie function
Sertoli cell-only syndrome
