摘要
目的探究复方斑蝥胶囊联合化疗对进展期胃癌患者的临床疗效.方法选择南昌大学第一附属医院普外科2014-01/2014-12收治的80例进展期胃癌术后患者,所有患者均行D2根治术且术后病理按UICC/AJCC第7版TNM分期标准证实为Ⅱb-Ⅲc期,随机分为治疗组和对照组,每组各40例.对照组患者采用单纯XELOX化疗方案进行治疗,治疗组患者在采用XELOX化疗方案的同时联合复方斑蝥胶囊(康赛迪),比较两组患者的临床疗效、生活质量以及不良反应发生情况.结果治疗组患者KPS评分提高优于对照组、不良反应发生率小于对照组,具有统计学差异(P<0.05);治疗组与对照组的3年生存率无统计学差异(P>0.05),但治疗组生存率较对照组有升高的趋势.结论复方斑蝥胶囊能减少进展期胃癌患者化疗不良反应,提高患者生活质量及化疗依从性,值得临床推广.
AIM To evaluate the efficacy of Compound Banmao Capsules combined with chemotherapy in the treatment of patients with advanced gastric carcinoma.METHODS Eighty patients with advanced gastric carcinoma treated from January 2014 to December 2014 at our department were randomly divided into either a study group or a control group. All of the patients had undergone radical gastrectomy with D2 lymphadenectomy. According to the UICC/AJCC TNM staging system for gastric cancer （seventh edition）, all of the patients were confirmed to have stage Ⅱb-Ⅲc disease. The patients in the control group were treated with XELOX chemotherapy only, and the patients in the study group were treated with XELOX chemotherapy plus Compound Banmao Capsules. After treatment, clinical efficacy, quality of life, and adverse reactions were compared between the two groups.RESULTS The Kamofsky performance score was significantly better and the incidence of adverse reactions was significantly lower in the study group than in the control group （P 〈 0.05）. There was no significant difference in the 3-year survival rate between the two groups （P 〉 0.05）. However, the survival of patients in the study group showed an increasing tendency compared with the control group.CONCLUSION Compound Banmao Capsules may reduce the adverse effects of chemotherapy and improve the quality of life and compliance of patients with gastric cancer.
作者
高攀
揭志刚
李正荣
曹毅
张国阳
熊建波
肖伟
刘逸
Pan Gao;Zhi-Gang Jie;Zheng-Rong Li;Yi Cao;Guo-Yang Zhang;Jian-Bo Xiong;Wei Xiao;Yi Liu(Department of General Surgery, the First Affiliated Hospital of Nanchang University, Jiangxi Province, Chin)
出处
《世界华人消化杂志》
CAS
2018年第11期655-660,共6页
World Chinese Journal of Digestology
基金
江西省卫生厅中医药科研基金资助项目
No.2013A069~~
关键词
复方斑蝥胶囊
XELOX化疗
进展期胃癌
生活质量
Compound Banmao Capsules
XELOXchemotherapy
Advanced gastric carcinoma
Quality of life
