摘要
目的:探讨剖宫产后瘢痕子宫患者采取米非司酮引产的临床效果。方法:选择2015年1月至2017年12月期间在河南省信阳市职业技术学院附属医院引产的94例剖宫产后瘢痕子宫患者作为研究对象,按随机数表法分成2组,各47例。对照组经羊膜腔注射依沙吖淀,观察组在此基础上使用米非司酮,比较两组引产成功率、用药到宫缩时间、宫缩到胚胎娩出时间、产后出血量、不良事件及并发症发生情况。结果:观察组引产成功率较对照组高,差异有统计学意义(P<0.05);观察组用药到宫缩时间、宫缩至胎儿娩出时间均短于对照组,且产后出血量较对照组少,差异有统计学意义(P<0.05);观察组子宫破裂、软阴道损伤、残留胎盘的发生率均略低于对照组,但差异无统计学意义(P>0.05);观察组恶心呕吐、头晕头痛、发热等不良反应发生率略高于对照组,但差异无统计学意义(P>0.05)。结论:剖宫产后瘢痕子宫患者采取依沙吖啶联合米非司酮用于引产,可显著缩短引产时间、减少出血量,提高引产成功率,降低不良事件发生率。
Objective： To investigate the clinical effect of mifepristone induced labor in patients with scar uterus after cesarean section. Methods： From August 2015 to August 2017, 94 patients with scar uterus after cesarean section in our hospital were selected as the study objects. According to the method of random number, they were divided into two groups, with 47 cases each. The control group was injected with esarridine via amniotic cavity, and the observation group was treated with mifepristone on this basis. The success rate of induced labor, the time to uterine contraction, the time from uterine contraction to embryo delivery, the amount of postpartum bleeding and the occurrence of adverse events were compared between the two groups. Results： The success rate of induced labor in the observation group was higher than that in the control group（P〈0.05）： the time of uterine contraction in the observation group was shorter than that of the control group, and the amount of postpartum hemorrhage was less than the control group, and the difference was statistically significant（P〈0.05）. The incidence of uterine rupture, soft vaginal injury and residual placenta in the observation group were slightly lower than that of the control group, but the difference was not statistically significant（P〉0.05）. Conclusion： After cesarean section, there is no significant difference between the two groups. Ethacridine combined with mifepristone for induction of labor can shorten the time of induction, reduce the amount of bleeding, increase the success rate of induction, and reduce the incidence of adverse events.
作者
刘源
LIU Yuan(Department of Obstetrics and Gynecology, the Affiliated Hospital of Career Technical College, Xinyang Henan 464000, Chin)
出处
《药品评价》
CAS
2018年第9期61-64,共4页
Drug Evaluation
关键词
剖宫产后瘢痕子宫
引产
米非司酮
不良事件
Scar Uterus After Cesarean Section
Induced Labor
Mifepristone
Adverse Events
