摘要
本论文成功设计了一条全新的合成4,4,4-三氟3-(3-吲哚)丁酸异丙酯的路线。以吲哚为起始原料,经过酰化反应、wittig反应、还原、水解、酯化五步反应,得到一个新的化合物4,4,4-三氟3-(3-吲哚)丁酸异丙酯。对合成的中间体及目标化合物通过MS、~1H NMR、^(13)C NMR等谱学手段进行结构表征。
Isopropyl-4,4,4-trifluoro-3-（1H-indol-3-yl） butanoate was obtained successfully in this paper. The new route was de- signed through five steps reactions with indole as starting materials, after aeylation reaction, wittig reaction, reduction, hydrolysis and e sterifieation reaction. The isopropyl-4,4,4-trifluoro-3- （1H-indol-3-yl）-butanoate （5）was a new compound. The structures of inter- mediates and target compounds were characterized by means of 1H NMR,13C NMR and MS.
作者
于超
孙肇昱
刘冉
薛中原
陶波
王爱玲
YU Chao;SUN Zhao-yu;Liu Ran;XUE Zhong-yuan;TAO Bo;WANG Ai-ling(College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China;Agricultural College, Northeast Agricultural University, Harbin 150030, China;Liaoning Entry-Exit Inspection and Quarantine Bureau, Dalian 116622, China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2018年第5期808-812,共5页
Chemical Research and Application
基金
国家自然科学基金项目(21506018)资助
辽宁酋博士科研启动基金项目(201601308)和大连大学博士启动基金项目(20152QL011)资助
