摘要
[目的]探讨强直性脊柱炎(AS)早发髋关节强直的相关因素,为选择恰当的治疗方案提供依据。[方法]搜集AS患者1 000例,记录患者的一般情况,AS早发髋关节强直阳性家族史,临床表现,实验室检查数据,放射学检查结果。采用Logistic回归的方法筛选出AS早发髋关节强直的相关因素,建立Logistic回归模型,显示其相关的危险性。[结果]在AS患者中共有早发髋关节强直182例,占全部病例的18.20%,占髋关节疼痛者的55.49%。单因素分析结果显示,HLA-B27、血沉、病程、起病时骶髂关节炎、持续肌腱端炎、髋关节疼痛、阳性家族史与早发髋关节强直具有相关性。多因素分析显示与早发髋关节强直相关的临床因素包括,HLA-B27、阳性家族史、持续肌腱端炎、髋关节疼痛。[结论]AS早发髋关节强直的相关危险因素有:HLA-B27阳性、持续肌腱端炎、髋关节疼痛、家族史有早发髋关节强直。当出现以上危险因素,应早期积极进行针对性干预治疗,减轻或延缓髋关节强直的进展,避免髋关节残疾的发生。
[Objective] To explore the factors related to premature hip ankylosis in ankylosing spondylitis（AS） to provide the basis for selecting appropriate treatment. [Methods] A total of 1 000 AS patients were collected for this survey. The general condition of the patient, family history of premature hip ankylosis, clinical manifestations, laboratory data and radiological findings were recorded. Subsequently to logistic regression used to screen the factors related to premature hip ankylosis, the logistic regression model was established to show the related risk. [Results] There were 182 patients proved premature hip ankylosis among those AS patients, accounting for 18.2% of all patients and accounting for 55.49% of patients with hip pain. Univariate analysis showed that HLA-B27, ESR, duration of the disease, onset of sacroiliac joint inflammation, persistent tendon inflammation, hip pain, and positive family history were associated with premature hip ankylosis. In addition, multivariate analysis demonstrated that the clinical factors associated with premature hip ankylosis included HLA-B27, positive family history, persistent tendon inflammation, and hip pain. [Conclusion] The risk factors of premature hip ankylosis in AS include HLA-B27 positive,persistent tendon inflammation, hip pain, family history of premature hip ankylosis. As long as the above risk factors noted in patients, early and targeted intervention should be taken to reduce or delay the progress of hip ankylosis and avoid the occurrence of hip joint disability.
作者
熊春翔
卫小春
尹东
黄宇
梁斌
孙可
丘德赞
韦建勋
范锲
石泽锋
XIONG Chun-xiang1,2,WEI Xiao-chun3,YIN Dong2,HUANG Yu2,LIANG Bin2,SUN Ke2,QIU De-zan2,WEI Jian-xun2,FAN Qie2,SHI Ze-feng2(1. Postdoctoral Research Co-culture Station of People＇s Hospital of Guangxi Zhuang Autonomous Region And Shanxi Medical University, Nanning 530021, China; 2.Orthopedic Department, People＇s Hospital, Guangxi Zhuang Autonomous Region, Nanning 530021, China; 3. Department of Orthopedics, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Chin)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2018年第9期798-801,共4页
Orthopedic Journal of China
基金
广西重点研发计划(编号：桂科AB16380230)
广西自然科学基金(编号：桂科基2015GXNSFAA139200)
广西医药卫生自筹经费计划课题(编号：Z2016609)
