摘要
研究显示，成纤维细胞生长因子（FGF）1、FGF19、FGF21及FGF23参与糖代谢调节。FGF1主要通过抑制下丘脑-垂体-肾上腺轴、减少肝脏乙酰辅酶A合成、增强胰岛素敏感性以及中枢机制发挥降糖作用。FGF19具有增加糖原和蛋白质合成，减少糖异生的作用。FGF21的降糖机制包括促进胰岛素分泌、增加胰岛素敏感性、提高糖代谢及抑制胰高血糖素的分泌。FGF23与糖代谢有关，但机制尚不明确。其中FGF1降糖效果最显著，FGF家族可能成为糖尿病治疗的新靶点。
Many studies have shown that fibroblast growth factor （FGF）1, FGF19, FGF21 and FGF23 were involved in glucose metabolism. FGF1 could lower blood glucose by suppression of hypothalamic pituitary adrenal axis, reducing the synthesis of aeetyl coenzyme A, enhancing insulin sensitivity, and the central effect. FGF19 had the effect of increasing glycogen and protein synthesis and reducing glueoneogene- sis. The antidiabetic mechanisms of FGF21 included promoting the secretion of insulin, increasing the sensi- tivity of insulin, enhancing glucose metabolism and inhibiting glucagon secretion. FGF23 was related to glu- cose metabolism, but the mechanism is unclear. Among them, the effects FGF1 are more significant. FGF family may become a new target for the treatment of diabetes mellitus.
作者
叶燕珍
杜建玲
Ye Yanzhen;Du Jianling.(Department of Endo- crinology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of Endocrinology, The Third Affiliated Hospital of Dalian Medical University, Dalian 116200, China)
出处
《国际内分泌代谢杂志》
2018年第3期200-203,212,共5页
International Journal of Endocrinology and Metabolism
关键词
成纤维细胞生长因子
糖代谢
糖尿病
Fibroblast growth factor
Glucose metabolism
Diabetes mellitus
