摘要
目的探讨糖皮质激素联合长效β2受体激动剂治疗稳定期慢性阻塞性肺疾病（COPD）的临床效果。方法选取206例稳定期COPD患者，随机分为观察组和对照组，每组各103例。对照组给予常规治疗，观察组在常规治疗的基础上给予吸入糖皮质激素和长效β2受体激动剂。两组疗程均为3个月。结果观察组和对照组疗效差异有统计学意义（P=0．012），观察组治疗总有效率高于对照组（P=0．024）。两组治疗患者在肺功能和血气指标方面的差异有统计学意义（P〈0．05）。观察组治疗期间的急性加重风险低于对照组（P=0.018）。结论糖皮质激素和长效β2受体激动剂联合治疗稳定期C0PD临床效果显著，在缓解症状、改善肺功能等方面优于传统疗法，值得临床推广。
Objective To explore the combined effect of glucocorticoids and long-acting β 2 receptor agonist in the treatment of stationary phase COPD. Methods 206 stable COPD cases in the study were randomly separated into an experimental group and a control group. The control group received conventional therapy and the experimental group additionally received inhalation glucocorticoids （ ICS ） and long-acting β2 receptor agonist （ LABA ） . The course of treatment was 3 months. Results The differences of curative effect in the two groups were significant （ P=0.012 ） . The total effective rate of the experimental group was higher than in the control group （ P=0.024 ） . There were significant differences of lung function and blood gas index in the two groups （ P〈0.05 ） . The risk of acute exacerbation during the treatment course was lower in the experimental group than in the control group （P=0.018 ） . Conelusion The clinical curative effect of ICS and LABA in the treatment of stable COPD is effective. It is more valuable than the traditional therapy in relieving symptoms and improving lung function, and is worthy of clinical promotion.
出处
《浙江临床医学》
2018年第6期1032-1033,共2页
Zhejiang Clinical Medical Journal
关键词
慢性阻塞性肺疾病
糖皮质激素
长效Β2受体激动剂
Chronic obstructive pulmonary disease
Glucocorticoids
Long-acting β 2 receptor agonist
