摘要
中枢神经系统炎症反应在AD发病过程中发挥重要作用，促炎因子可引起机体炎症反应，增强β淀粉样蛋白（AB）引起的神经毒性作用，促进AD发病；抗炎因子则能够下调炎症反应，发挥保护作用并促使受损组织重建。然而，基因多态性的存在使得炎性因子对AD发病的影响错综复杂，在不同种群中存在很大的差异，研究并阐明炎性因子基因多态性与AD发病的关系有助于AD发病机制的研究，并为AD的治疗提供新的线索。故本文围绕上述内容综述如下。
The central nervous system inflammatory response plays an important role in the pathogenesis of AD. Pro-inflammatory cytokines can induce inflammatory reactions in the body, enhance the neurotoxic effects caused by Aβ, promote the pathogenesis of AD and anti-inflammatory factors can down-regulate the inflammatory response, play a protective role and promote the reconstruction of damaged tissue. However, due to the existence of genetic polymorphisms, the influence of inflammatory factors on AD is complicated, especially in different population groups. Studing and clarifying the relationship between gene polymorphisms of inflammatory factors and and the pathogenesis of AD will promote the study of the mechanism of AD and provide a new method for the treatment of AD. Therefore, this article mainly reviews this.
作者
李倩倩
李兰珺
丁单华
张爽
吴军
Li Qianqian;Li Lanjun;Ding Danhua;Zhang Shuang;Wu Jun(Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Chin)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2018年第6期640-644,共5页
Chinese Journal of Neuromedicine
基金
国家自然科学基金（U1604181）
河南省基础与前沿技术研究计划项目（142300410390）
关键词
阿尔茨海默病
炎性因子
基因多态性
Alzheimer＇s disease
Inflammatory cytokines
Gene polymorphisms
