盐酸米诺环素对固定正畸牙龈炎患者龈沟液中前列腺素E_2及人基质金属蛋白酶8水平的影响被引量：6

Influence of Minocycline Hydrochloride on the levels of prostaglandin E_2 and human matrix metalloproteinase-8 in gingival crevicular fluid in the patients with fixed orthodontic gingivitis

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摘要目的探讨盐酸米诺环素对固定正畸牙龈炎患者龈沟液中前列腺素E2(PGE2)、白细胞介素-1β(IL-1β)及人基质金属蛋白酶8(MMP-8)水平的影响。方法将2015年11月~2017年8月因固定正畸牙龈炎于我院就诊的80例患者纳入研究并依据随机数字表法分为对照组和观察组,各40例。对照组给予常规口腔卫生保健措施治疗,观察组则联合盐酸米诺环素治疗,每周1次。4周后比较两组治疗前后的出血指数(SBI)、探查深度(PD)改善情况以及两组龈沟液中的PGE2、IL-1β及MMP-8水平改善情况。结果治疗后观察组的龈沟SBI、PD低于对照组,差异有统计学意义(P<0.05)。治疗后观察组龈沟液中的PGE2、IL-1β及MMP-8水平低于对照组,差异有统计学意义(P<0.05)。结论盐酸米诺环素可有效改善固定正畸牙龈炎,降低龈沟液中炎性指标及疼痛介质水平,值得推广。 Objective To investigate the influence of Minocycline Hydrochloride on the levels of prostaglandin E2（PGE2）,interleukin-1β（IL-1β） and human matrix metalloproteinase 8（MMP-8） in gingival crevicular fluid in the patients with fixed orthodontic gingivitis.Methods From November 2015 to August 2017,80 patients admitted to our hospital with fixed orthodontic gingivitis were selected and divided into the control group and the observation group according to the random digital table method,40 cases in each group.The control group was given conventional oral health care,and the observation group was given combined Minocycline Hydrochloride,once a week.After four weeks,the improvement of bleeding index（SBI） and exploration depth（PD） before and after treatment was compared.The improvement of PGE2,IL-1β and MMP-8 levels in gingival crevicular fluid was compared between the two groups after 4 weeks.Results After treatment,the SBI and PD of gingival sulcus in the observation group were lower than those in the control group,and the difference was statistically significant（P〈0.05）.After treatment,the levels of PGE2,IL-1β and MMP-8 in gingival crevicular fluid in the observation group were lower than those in the control group,and the difference was statistically significant（P〈0.05）.Conclusion Minocycline Hydrochloride can effectively improve the fixed orthodontic gingivitis and reduce the inflammation index and pain media levels in gingival crevicular fluid,which is worthy of popularization.

作者颜明宋燿光 YAN Ming1,SONG Yao-guang2(1.Department of Stomatology,the Second Hospital of Fuzhou City in Fujian Province,Fuzhou 350007,China;2,Department of Clinical Medicine,Fujian Medical University,Fuzhou 350108,Chin)

机构地区福州市第二医院口腔科福建医科大学临床医学部

出处《中国当代医药》 2018年第14期116-118,共3页 China Modern Medicine

关键词盐酸米诺环素固定正畸牙龈炎龈沟液前列腺素E2 基质金属蛋白酶8 Minocycline Hydrochloride Fixed orthodontic gingivitis Gingival crevicular fluid Prostaglandin E2 Matrix metalloproteinase 8

分类号 R781.41 [医药卫生—口腔医学]