期刊文献+

观察化学发光免疫法在肿瘤生物标志物检验中的运用效果 被引量:7

Observation on Application Effect of Chemiluminescent Immunoassay in Testing the Tumor Biomarkers
在线阅读 下载PDF
导出
摘要 目的分析化学发光免疫法在肿瘤生物标志物检验中的运用效果。方法方便选择该院2016年1月—2017年1月抽取的416例原发性的肿瘤患者作为研究组,再择同期至院内体检416名健康者作为对照组;对两组皆实施化学发光免疫法实施肿瘤生物的标志物检验,比对两组检验结果。结果 CA199研究组是(52.30±9.51)U/m L,高于对照组(5.39±0.72)U/m L(P<0.05);CEA研究组阳性检出率是82.21%(342/416),比对照组0.00%(0/416)高(P<0.05);联合检出阳性率对照组是1.68%(7/416),低于研究组96.39%(401/416)(χ2=746.603 0,P<0.05)。结论化学发光免疫法应用于肿瘤生物的标志物检验中效果明显。 Objective To analyze the application effect of chemiluminescent immunoassay in testing the tumor biomarkers.Methods 416 cases of patients with primary tumors treated in our hospital from January 2016 to January 2017 were convenient convenient selected as the research group, while 416 cases of healthy people for physical examination in our hospital were selected as the control group, and the tumor biomarkers of the two groups were tested by the chemiluminescent immunoassay, and the test results were compared between the two groups. Results The CA199 in the research group was higher than that in the control group, [(52.30±9.51) U/m L vs(5.39±0.72) U/m L](P〈0.05), and the positive test rate of CEA in the research group was higher than that in the control group [82.21%(342/416) vs 0.00%(0/416)](P〈0.05), and the positive rate of combined test in the control group was higher than that in the research group [1.68%(7/416) vs 96.39%(401/416)](χ2=746.603 0,P〈0.05). Conclusion The application effect of chemiluminescent immunoassay in testing the tumor biomarkers is obvious.
作者 宋瑞卿 SONG Rui-qing(Department of Clinical Laboratory,Xinwen Mining Group Central Hospital,Tai'an,Shandong Province,271200 China)
出处 《中外医疗》 2018年第17期17-19,共3页 China & Foreign Medical Treatment
关键词 肿瘤 化学发光免疫法 检验 生物标志物 Tumor Chemilumineseent immunoassay Test Biomarker
  • 相关文献

参考文献12

二级参考文献101

  • 1Ganepola AP Ganepola,Joel Nizin,John R Rutledge,David H Chang.Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer[J].World Journal of Gastrointestinal Oncology,2014,6(4):83-97. 被引量:11
  • 2Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-386.
  • 3Badila E,Japie C,Barto?D.Cancer biomarkers in clinical practice[J].Rom J Intern Med,2014,52(4):223-232.
  • 4Litchfield K,Shipley J,Turnbull C.Common variants identified in genome-wide association studies of testicular germ cell tumour:an update,biological insights and clinical applica-tion[J].Andrology,2015,3(1):34-46.
  • 5Ellinger J,Müller SC,Dietrich D.Epigenetic biomarkers in the blood of patients with urological malignancies[J].Expert Rev Mol Diagn,2015,15(4):505-516.
  • 6Kratz CP,Edelman DC,Wang Y,et al.Genetic and epigenetic analysis of monozygotic twins discordant for testicular cancer[J].Int J Mol Epidemiol Genet,2014,5(3):135-139.
  • 7Feinberg AP,Tycko B.The history of cancer epigenetics[J].Nat Rev Cancer,2004,4(2):143-153.
  • 8Sharma S,Kelly TK,Jones PA.Epigenetics in cancer[J].Carcinogenesis,2010,31(1):27-36.
  • 9Goldberg AD,Allis CD,Bernstein E.Epigenetics:a landscape takes shape[J].Cell,2007,128(4):635-638.
  • 10Lopez-Serra L,Esteller M.Proteins that bind methylated DNA and human cancer:reading the wrong words[J].Br J Cancer,2008,98(12):1881-1885.

共引文献163

同被引文献29

引证文献7

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部