摘要
目的观察临床应用瑞舒伐他汀联合盐酸小檗碱治疗急性缺血性脑梗死患者对相关指标的影响。方法采用前瞻性研究方法,将2016年4月至2017年7月山东省青岛市海慈医疗集团收治的120例急性缺血性脑梗死患者按照随机数字表法随机分为对照组和观察组,每组各60例,对照组采用瑞舒伐他汀治疗,观察组采用瑞舒伐他汀联合应用盐酸小檗碱治疗,对比分析两组患者治疗前后血脂指标、动脉粥样硬化斑块相关指标及超敏C反应蛋白(hsCRP)和氧化低密度脂蛋白(ox-LDL)水平。结果治疗前两组患者血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)以及低密度脂蛋白胆固醇(LDL-C)水平组间比较差异不具统计学意义(P>0.05),治疗后两组TC、TG、LDL-C均较治疗前明显下降(P<0.05),HDL-C水平明显升高,观察组各指标变化幅度明显高于对照组(P<0.05),治疗前两组患者颈动脉内膜中层厚度(IMT)、Crouse积分以及不稳定斑块数目组间比较差异不具统计学意义(P>0.05),治疗后两组各指标均较治疗前明显下降(P<0.05),观察组下降幅度明显高于对照组(P<0.05),治疗前两组患者超敏C反应蛋白(hs-CRP)和氧化低密度脂蛋白(ox-LDL)水平组间比较差异不具有统计学意义(P>0.05),治疗后两组患者hs-CRP和ox-LDL水平均较治疗前明显下降(P<0.05),观察组患者各指标下降幅度明显高于对照组(P<0.05)。结论临床应用瑞舒伐他汀联合盐酸小檗碱治疗急性缺血性脑梗死可明显改善患者血脂水平,降低炎症反应及动脉粥样硬化斑块发生,可在临床推广应用。
Objective To observe the effect of Risuvastatin combined with Berberine hydrochloride on relevant indicators in the treatment of patients with acute ischemic cerebral infarction. Methods 120 patients with acute ischemic cerebral infarction treated in Haici medical group,Qingdao City,Shandong province from April 2016 to July 2017 were randomly divided into control group and observation group according to random digital table method,with 60 cases in each group. The control group was treated with rosuvastatin,and the observation group was treated with rosuvastatin combined with Berberine hydrochloride. The blood lipid index,atherosclerotic plaque related index,hypersensitive C reaction protein（ hs-CRP） and oxidized low density lipoprotein（ ox-LDL） were compared and analyzed in the two groups. Results The TC,TG,LDL,LDL-C,HDL-C level in two groups before treatment had no statistically significant difference（ P〉0. 05）,TC,TG,LDL-C level in the two groups after treatment significantly decreased than those before treatment（ P〈0. 05）,HDL-C level obviously increased,the index change in observation group was obviously higher than that of control group（ P〈0. 05）,IMT,Crouse integral,and the number of unstable plaque group in the two groups before treatment had no statistically significant difference（ P〉0. 05）,after treatment,each index was significantly decreased（ P〈0. 05）,and those in observation group were obviously higher than those of control group（ P〈0. 05）,hs-CRP and ox-LDL level before treatment had no statistically significant difference（ P〉0. 05）,after treatment,the hs-CRP and ox-LDL levels significantly decreased than before treatment（ P〈0. 05）,various index decrease in observation group was obviously higher than that of control group（ P〈0. 05）. Conclusion The clinical application of rosuvastatin combined with berberine hydrochloride in the treatment of acute ischemic cerebral infarction can obviously improve the level of blood lipid,reduce the inflammation and atherosclerotic plaque,and can be used in clinical application.
作者
卢海燕
崔换新
杨晓华
刘春芬
LU Hal - yan;CUI Huan -xin;YANG Xiao -hua(Department of Neurology;Department of Nephrotic ENT;Department of Ski,Haici Medical Group of Qingdao,Qingdao Shangdong 266033,China.)
出处
《临床和实验医学杂志》
2018年第16期1729-1732,共4页
Journal of Clinical and Experimental Medicine
基金
山东省教育厅科研课题(编号:3035b2078)
关键词
急性缺血性脑梗死
瑞舒伐他汀
盐酸小檗碱
Acute ischemia cerebral infarction
Resuvastatin
Berberine hydrochloride
