摘要
目的分析重症颅脑损伤术后脑梗死患者血清巨噬细胞移动抑制因子(MIF)、趋化素样因子-1(CKLF1)及不规则趋化因子(FKN)水平变化及其临床意义。方法选取重症颅脑损伤术后继发脑梗死患者75例(研究组)、健康志愿者25例(对照组),比较两组间及研究组中不同亚组的血清MIF、CKLF1及FKN水平,分析血清MIF、CKLF1、FKN水平与脑梗死体积、美国国立卫生研究院卒中量表(NIHSS)评分的相关性。结果研究组发病24 h内血清MIF、CKLF1及FKN均高于对照组(P<0.05),且随病情加重,患者血清MIF、CKLF1、FKN水平增加(P<0.05);预后良好组发病24 h内MIF、CKLF1、FKN、NIHSS评分、脑梗死体积低于预后不良组(P<0.05);患者发病24 h内血清MIF、CKLF1、FKN水平均与NIHSS评分、脑梗死体积呈正相关(P<0.05)。结论监测重症颅脑损伤术后脑梗死患者发病24 h时的血清MIF、CKLF1、FKN水平,对病情及预后均有一定评估价值,值得在临床推广应用。
Objective To analyze the changes of serum macrophage migration inhibitory factor （MIF）, chemokine-like factor-1 （CKLF1） and irregular chemokine Fractalkine （FKN） levels in the patients with cerebral infarction after operation for severe craniocerebral injury and its clinical significance. MeAods A total of 75 patients with secondary cerebral infarction after operation for severe craniocerebral injury （“Study Group冶”）and another 25 healthy volunteers （“ Control Group”）were selected. The serum MIF, CKLF1 and FKN levels between the two groups and within the study group were compared, and the relevance of the serum MIF, CKLF1, FKN levels with the cerebral infarction volume and National Institutes of Health Stroke Scale （NIHSS） scores was analyzed. Results The serum MIF, CKLF1 and FKN levels in the study group within 24 h were higher than those in the control group （P 〈 0.05）, and the serum MIF, CKLF1 and FKN levels increased with the severity of the disease （P 〈 0.05）. The MIF, CKLF1, FKN, NIHSS scores, and the cerebral infarction volume in the good prognosis group within 24 h since the incidence were all lower than those in the poor prognosis group （P 〈 0.05）, and the serum MIF, CKLF1, and FKN levels of the patients within 24 h since the incidence were positively correlated with NIHSS scores and cerebral infarction volume （P 〈 0.05）. Conclusion The monitoring of the serum MIF, CKLF1 and FKN levels of the patients with cerebral infarction within 24 h since the incidence has certain evaluation value for the disease condition and prognosis, and it is worthy of clinical application.
作者
罗泽兵
杨敏
丁方东
包晴
谢东
邓文彬
Luo Zebing;Yang Min;Ding Fangdong;Bao Qing;Xie Dong;Deng Wenbin(Department of General Surgery,AffiliatedHospital of Leshan Vocational and Technical College,Emeishan,Sichuan,614218,China;Department of Anesthesiology,Affiliated Hospital of Leshan Vocational and Technical College,Emeishan,Sichuan,614218,China;Department of General Surgery,Emeishan People＇s Hospital,Emeishan,Sichuan,614200,China)
出处
《西南国防医药》
CAS
2018年第6期516-518,共3页
Medical Journal of National Defending Forces in Southwest China
