摘要
目的综合评价白细胞介素-4基因(IL-4)启动子区rs2243250多态(-590C>T)与牙周炎易感性的关系。方法搜集所有符合标准的病例-对照研究,运用Meta分析方法计算IL-4基因rs2243250多态与牙周炎易感性关系的OR值,并进行亚组分析、敏感性分析和文献的发表偏倚检验。结果本次Meta分析共纳入15篇文献(18个数据组),累计病例1698例,对照2247例。结果显示,IL-4基因rs2243250多态与牙周炎患病风险无关(显性遗传模型:OR=1.33[0.80,2.19],P=0.27;隐性遗传模型:OR=1.05[0.62,1.80],P=0.19)。按牙周炎类型行亚组分析,未发现IL-4基因rs2243250多态与侵袭性牙周炎或慢性牙周炎的患病风险相关;按人种及对照来源进行亚组分析,亦未发现该位点和牙周炎患病风险的关联。结论 IL-4基因rs2243250多态与牙周炎患病风险无关。
Objective To assess the association between rs2243250 polymorphism of IL-4 gene promoter and periodontitis susceptibility using comprehensive meta-analysis. Methods We searched for all case-control studies on the association between rs2243250 polymorphism of IL-4 gene promoter and periodontitis susceptibility. Odds ratios and 95%confidence interval were calculated. Publication bias test, subgroup analysis, and sensitivity analysis were also performed.Results A comprehensive meta-analysis was conducted on 17 case-control studies including 1,698 patients and 2,247 matched control subjects. Results showed that rs2243250 polymorphism was not associated with periodontitis risk（dominant model： OR=1.33 [0.80, 2.19], P=0.27; recessive model： OR=1.05 [0.62, 1.80], P=0.19）. In addition, when stratified separately by disease type, we found that rs2243250 SNP was not associated with aggressive periodontitis or chronic periodontitis. Subgroup analysis of race and/or source of control showed no significant association in any of the comparison models tested. Conclusion These findings indicated that rs2243250 polymorphism was not associated with periodontitis risk.
作者
胡永青
陈树珍
段少秋
霍向然
李琰
周荣秒
王娜
HU Yongqing;CHEN Shuzhen;DUAN Shaoqiu;HUO Xiangran;LI Yan;ZHOU Rongmiao;WANG Na(Department of Oral Medicine,Stomatological Hospital,Hebei Medical University,Shijiazhuang 050017)
出处
《现代口腔医学杂志》
CAS
2018年第4期205-208,212,共5页
Journal of Modern Stomatology
基金
河北省自然科学基金(H2015206471)
