摘要
目的:探讨加味清胃汤在慢性牙周炎疾病治疗前后对其牙周状况、炎症因子水平和前列腺素E2(PGE2)水平及中医证候积分的影响。方法:选择114例慢性牙周炎患者,按照随机数字表法,将患者分为研究组和对照组,每组57例。对照组患者口服罗红霉素片+甲硝唑片,研究组在甲硝唑片基础上加用加味清胃汤治疗,14d为1个疗程,连续服用6个疗程。观察两组患者牙周状况(菌斑指数(PLI)、牙齿松动度(TM)、龈沟出血指数(SBI))、炎症因子水平(肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)、白介素-1β(IL-1β))、PGE2以及中医证候积分(口臭、牙龈肿痛、口干舌燥、便秘、齿衄)的变化。结果:治疗前两组各项指标比较均无统计学意义(P均>0.05);治疗后(1)研究组牙周状态各项指标与对照组比较均降低(P<0.05);(2)炎症因子水平以及PGE2水平研究组与对照组比较均降低(P<0.05);(3)中医证候积分研究组患者各项指标评分均降低(P<0.05)。结论:加味清胃汤应用于慢性牙周炎患者的治疗中,可以明显改善患者的牙龈肿痛、口臭、便秘等疾病表现症状,通过降低炎性因子的各项水平促进疾病的逐渐消除,减少了牙菌斑的分布,显著改善了患者的牙周状况,提高了患者的生活质量。
Objective：To investigate the effect of Jiawei qingwei decoction on periodontal status,inflammatory cytokines,prostaglandin E2（PGE2）levels and TCM syndrome scores before and after chronic periodontitis treatment.Methods：114 patients with chronic periodontitis were chosen.They were divided into the study group and the control group according to the random number table method,and 57 cases in each group.Patients in the control group were treated with roxithromycin tablets and metronidazole tablets orally.The study group was treated with Jiawei Qingwei Decoction on the basis of metronidazole tablets.14 days were as a course,and they were treated for 6 courses.The changes of periodontal status（PLI,TM,SBI）and levels of inflammatory cytokines（tumor necrosis factor-α（TNF-α）,high-sensitivity C-reactive protein（hsCRP）,interleukin-6（IL-6）,interleukin-1β（IL-1β））,PGE2 and TCM syndrome scores（（Bad breath,swollen gums,dry mouth,constipation,gum bleeding）of the two groups were observed.Results：There were no significant differences between the two groups before treatment（P〉0.05）.After treatment,（1）the indexes of periodontal status in study group were lower than those in control group（P〈0.05）.（2）The levels of inflammatory cytokines and PGE2 were all decreased in the study group and the control group（P〈0.05）.（3）The score of each index in TCM syndrome in the study group were all decreased（P〈0.05）.Conclusion：Traditional Chinese medicine plus Qingwei Decoction application in the treatment of patients with chronic periodontitis,which can significantly improve the patients＇ symptoms such as gingivitis,bad breath and constipation,and promote the gradual elimination and reduction of the disease by reducing the levels of inflammatory factors and the distribution of dental plaque,can significantly improve the patient＇s periodontal status and improve the patient＇s quality of life.
作者
孔燕凌
徐月启
张乃晨
李瑞兰
Kong Yanling;Xu Yueqi;Zhang Naichen(The Second Chinese Traditional Hospital of Zhumadian in Henan Province（Zhumadian 463000)
出处
《陕西中医》
2018年第7期928-930,共3页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省医学科技攻关计划项目(201505113)
关键词
牙周炎/中西医结合疗法
@加味清胃汤
罗红霉素
甲硝唑
Periodontitis/ integrated Chinese traditional and western medicine therapy
@Jiawei Qingwei decoction
Roxithromycin
Metronidazole
