摘要
目的探讨头孢哌酮舒巴坦与乳糖阿奇霉素联合治疗小儿支气管肺炎的临床疗效。方法选取我院收治的98例支气管肺炎患儿为研究对象,根据硬币投掷法将其分为对照组和研究组,各49例。对照组给予头孢哌酮舒巴坦治疗,研究组在对照组的基础上联合乳糖阿奇霉素治疗。比较两组患儿的临床效果。结果研究组的治疗总有效率为93.88%,明显高于对照组的75.51%(P<0.05)。研究组患儿临床症状改善时间及住院时间均显著短于对照组(P<0.05)。治疗后,两组患儿IL-6、CRP及TNF-α水平均明显降低,且研究组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论头孢哌酮舒巴坦与乳糖阿奇霉素联合应用可有效改善患儿临床症状,降低血清炎性因子水平,疗效安全显著,值得推广使用。
Objective To explore the clinical effect of cefoperazone-sulbactam combined with azithromycin lactobionate inthe treatment of pediatric bronchopneumonia. Methods A total of 98 children with pediatric bronchopneumonia were selectedand divided into control group and study group according to coin throwing method, with 49 cases in each group. The controlgroup was given cefoperazone-sulbactam, and the observation group was treated with azithromycin lactobionate based on thecontrol group. The clinical effects of the two groups were compared. Results The total effective rate of the study group was93.88%, which was higher than 75.51% of the control group （P〈0.05）. The improvement time of clinical symptoms andhospital stays of the study group were shorter than those in the control group （P〈0.05）. After treatment, the levels of IL-6,CRP and TNF-琢 of the two groups decreased, and those in the study group were lower than the control group（P〈0.05）. Therewas no significant difference in total incidences of adverse reactions between the two groups （P 〉0.05）. ConclusionCefoperazone -sulbactam combined with azithromycin lactobionate in the treatment of pediatric bronchopneumonia caneffectively improve the clinical symptoms of children, reduce serum levels of inflammatory cytokines. It is safe and effective,which is worthy of promotion and appliction.
作者
王瑞阳
仵会茹
黄惠梅
WANG Rui-yang;WU Hui-ru;HUANG Hui-mei(Maternal and Child Health Hospital of Fuping County,Weinan 711711,China)
出处
《临床医学研究与实践》
2018年第18期104-105,共2页
Clinical Research and Practice
关键词
头孢哌酮舒巴坦
乳糖阿奇霉素
支气管肺炎
cefoperazone-sulbactam
azithromycin lactobionate
bronchopneumonia
