摘要
黄疸是新生儿期最常见的临床问题，胆红素脑病是新生儿高胆红素血症严重的并发症，早产儿血清总胆红素的水平与胆红素脑损伤的发生并不完全一致，也常缺乏典型的神经系统表现，加之早产本身就是发生胆红素脑病的高危因素，因此，胆红素在早产儿中引起的神经毒性仍是一个亟待解决的临床问题，对早产儿红素脑损伤的早期识别及干预是改善预后的关键。近年来，对胆红素神经毒性及早产儿红素临床表现有了更深入的研究，一些实验室指标及神经影像学的联合检测为早产儿胆红素脑损伤的早期诊断带来新的机遇。
Clinical jaundice is present in the majority of the newborns,while bilirubin encephalopathy is one of the most serious complications. Preterm birth is high risk factors of bilirubin encephalopathy. Premature infants may de- velop bilirubin - induced central nervous system （CNS） injury even at total serum bilirubin （ TSB ） levels conventionally considered to be non - neurotoxic, and less frequently show the typical abnormal neuromotor clinical signs. Preterm birth is one of the risk factors of bilirubin encephalopathy. The potential for bilirubin - induced neurotoxieity in the premature neonate remains a clinical concern, while efforts to improve current clinical assessment and early diagnosis are certainly needed. Recently research on the molecular and cellular mechanism of bilirubin neurotoxicity and the clinical manifesta- tions of bilirubin - induced CNS injury in the preterm neonate has made great progress, and it has been found that labo- ratory index and neuroimaging techniques are closely associated with early diagnosis of bilirubin - induced neurotoxicity in the preterm neonate.
作者
王箫
杜立中
Wang Xiao;Du Lizhong(Department of Neonatology,the Children＇s Hospital of Zhejiang University School of Medicine,Hangzhou 310003,China)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2018年第14期1041-1045,共5页
Chinese Journal of Applied Clinical Pediatrics
关键词
胆红素
婴儿
早产
神经毒性
早期监测
Bilirubin
Infant
premature
Neurotoxicity
Early diagnosis
