摘要
目的探讨反转录富含半胱氨酸蛋白(RECK)与基质金属蛋白酶-2(MMP-2)在子宫腺肌病中的表达及临床意义。方法选取我院2012年5月至2017年5月病理科石蜡存档包埋的96例组织标本作为研究对象,根据其标本来源将其分为A组(为子宫腺肌病异位内膜标本)36例、B组(为因子宫腺肌病切除子宫的在位内膜标本)34例和对照组(来自因其它妇科疾病而治疗的患者标本,均非子宫腺肌病)26例,根据资料结果记录三组患者的一般临床资料以及RECK和MMP-2的表达情况,分析其与子宫腺肌病的相关性。结果 (1)对照组和B组其RECK的阳性表达率均显著高于A组(P<0.05),但对照组和B组比较无差异(P>0.05);(2)A组和B组其MMP-2的阳性表达率均显著高于对照组(P<0.05),但A组与B租比较无统计学差异(P>0.05);(3)A组和B组其增生期和分泌期RECK的阳性表达率比较均无差异(P>0.05),但对照组增生期RECK的阳性表达率显著高于分泌期(P<0.05);(4)A组和B组其增生期和分泌期MMP-2的阳性表达率比较均无差异(P>0.05),但对照组分泌期MMP-2的阳性表达率显著高于增生期(P<0.05)。结论在子宫腺肌病患者中,MMP-2和RECK分别为较高和较低表达,其中MMP-2可能为促进子宫腺肌病发生的因素,而RECK可能是阻止子宫腺肌病发生的保护因素。
Objective To investigate the expression and clinical significance of reversion-inducing cysteine-rich protein with Kazal motifs（ RECK） and matrix metalloproteinase-2（ mmp-2） in adenomyosis. Methods A total of 96 paraffin-embedded tissue specimens collected by the Department of Pathology in our hospital from May 2012 to May 2017 were selected as subjects. According to the source,these specimens were divided into Group A of 36 cases（ ectopic endometrial specimens of adenomyosis）,Group B of 34 cases（ eutopic endometrium specimens for removal of uterine adenomyosis）,and control group of 26 cases（ specimens of patients with gynecological diseases other than adenomyosis）. The clinical data and expressions of RECK and MMP-2 in the three groups were recorded to analyze their correlations with adenomyosis. Results（ 1） The positive rates of RECK in the control group and Group B were significantly higher than those in Group A（ P〈0.05）,but there was no difference between the first two groups（ P〈0.05）.（ 2） The positive rates of MMP-2 in Group A and B were significantly higher than in control group（ P〈0.05）,but there was no significant difference between Group A and Group B（ P〈0.05）.（ 3） There was no significant difference in the positive expression rates of REK between proliferating and secretory stages in Group A and B（ P〈0.05）,but the positive expression rate of RECK in the proliferative phase of the control group was significantly higher than that in the secretory phase（ P〈0.05）.（ 4）There was no significant difference in the positive expression rate of MMP-2 between proliferating and secreting phases in Group A and Group B（ P〈0.05）,but the positive expression rate of MMP-2 in the secretory phase of the control group was significantly higher than that in the proliferative phase（ P〈0.05）. Conclusion In patients with adenomyosis,MMP-2 is of higher levels while RECK is of lower levels. MMP-2 may be a factor in the occurrence of adenomyosis,and RECK may be used as a protective factor for adenomyosis.
作者
王慧芳
金海红
王智文
WANG Huifang;JIN Haihong;WANG Zhiwen(Department of Gynaecology,the Frist Hospital of Qinhuangdao,Qinghuangdao Hebei,066000,Chin)
出处
《解放军预防医学杂志》
CAS
2018年第4期486-489,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
秦皇岛市科学技术研究与发展计划项目(No.201401A232)
关键词
反转录富含半胱氨酸蛋白
基质金属蛋白酶-2
子宫腺肌病
临床意义
reversion-inducing cysteine -ich protein with Kazal motifs
matrix metaUoproteinase-2
adenomy-osis
clinical significance
