摘要
目的了解营养支持对手足口病患儿血清微量元素、免疫球蛋白含量及临床表现的影响。方法收集2015年5月至2016年10月于秦皇岛市第三医院已确诊的手足口病(包括初次感染及反复感染者)住院患儿共100例,随机分为治疗组与对照组各50例,治疗组根据患儿年龄及病程给予个体化的营养支持治疗,对照组患儿仅给予常规治疗,比较两组患儿血清微量元素及免疫球蛋白含量的变化。结果治疗组患儿治疗后血清锌(4.83±1.57μg/ml)和钙(66.73±10.48μg/ml)水平均高于对照组,差异具有统计学意义(t=3.760、P=0.031,t=2.790、P=0.030)。治疗组患儿治疗后血清Ig A(1.99±0.31 mg/dl)和Ig G(13.74±2.86 mg/dl)水平均高于对照组,差异具有统计学意义(t=2.590、P=0.001,t=2.650、P=0.025)。治疗组患儿治疗后血清微量元素及免疫球蛋白水平失衡情况均较对照组显著改善。治疗组患儿发热时间及住院时间均显著短于对照组(t=15.512、P=0.036,t=10.202、P=0.001)。结论及时有效的营养支持有助于提高患儿免疫力,改善其临床结局。
Objective To investigate the effect of nutritional support treatment on blood trace elements, immunoglobulin content and clinical situation of children with hand, foot and mouth disease（HFMD）. Methods Total of 100 hospitalized children with confirmed HFMD（including primary infection and repeated infection） in the Third Hospital of Qinhuangdao from May 2015 to October 2016 were divided into treatment group and control group, randomly, with 50 cases in each group. The nutritional support treatment group according to the age and course of disease were given individualized, while the control group were only given routine treatment. The changes of the blood trace elements and immunoglobulin contents were compared. Results The levels of serum Zn（4.83 ± 1.57 μg/ml） and Ca（66.73 ± 10.48 μg/ml） of cases in treatment group after treatment were higher than those in control group, with significant differences（t = 3.760, P = 0.031; t = 2.790, P = 0.030）. The levels of serum Ig A（1.99 ± 0.31 mg/dl） and Ig G（13.74 ± 2.86 mg/dl） of cases in treatment group after treatment were higher than those in control group, with significant differences（t = 2.590, P = 0.001; t = 2.650, P = 0.025）. The imbalance of trace elements in blood and immunoglobulin levels of cases in treatment group after treatment were significantly improved compared with those of the control group. The fever and hospitalization period of cases in treatment group were significantly shorter than those of the control group（t = 15.512, P = 0.036; t = 10.202, P = 0.001）. Conclusions Timely and effective nutritional support could improve the immunity and clinical outcome of children.
作者
付华
李艳静
邢剑侠
马艳玲
温博
Fu Hua;Li Yanjing;Xing Jianxia;Ma Yanling;Wen Bo(Pediatrics;The Second Department of Respiratory;Fever Clinics,The Third Hospital of Qinhuangdao,Qinhuangdao 066000,China;Department of Medicine,Qinhuangdao Health School,Qinhuangdao 066000,China)
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2018年第3期288-291,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
2018年度河北省医学科学研究重点课题计划(No.20181202)
关键词
手足口病
营养支持
免疫力
Hand
foot and mouth disease
Nutritional intervention
Immunity
