摘要
目的探讨铜川地区肝癌与癌前病变患者γ-GT、AKP、SFe差异表达分析。方法收集2015年3月至2018年3月期间在铜川矿务局中心医院诊治的86例肝癌患者及癌前病变患者,以40例肝癌患者为肝癌组,46例癌前病变患者为癌前病变组,另外选取30例健康体检志愿者为对照组,分别检测三组对象血清AFP、CEA、γ-GT、AKP、SFe表达水平及阳性率。结果肝癌组及癌前病变组AFP、CEA、AKP、γ-GT及SFe水平均明显高于对照组(P<0.05),且肝癌组显著高于癌前病变组(P<0.05)。γ-GT在肝癌组的阳性率明显高于AFP和CEA(χ~2=5.952,18.620;P<0.05),同时AKP在肝癌组的阳性率显著高于CEA(χ~2=7.200,P<0.05);肝癌组AFP、CEA、AKP、γ-GT阳性率均明显高于癌前病变组和对照组(P<0.05)。AFP、CEA、AKP、γ-GT联合检测对肝癌的敏感性、特异性、阳性预测值及阴性预测值均明显高于AFP+CEA联合检测(P<0.05)。结论 AFP、CEA、AKP、γ-GT及SFe各指标在肝癌患者、癌前病变患者及正常健康者表达存在差异,且其联合检测可提高肝癌诊断的敏感性及特异性,可作为肝癌诊断的重要参考指标。
Objective To investigate the differential expressions of γ-GT,AKP,SFe in patients with hepatocellular carcinoma and precancerous lesions in Tongchuan. Methods From March 2015 to March 2018,eighty-six patients with liver cancer and precancerous lesions were diagnosed and treated in Central Hospital of Tongchuan Mining Bureau. Forty-six of these patients with precancerous lesions were assigned to the precancerous lesion group,and 40 patients with liver cancer were selected as the liver cancer group. In addition,thirty healthy volunteers served as the control group. Results The levels of AFP、CEA、γ-GT、AKP and SFe in the liver cancer group and in the precancerous lesion group were significantly higher than those of the control group（ P〈0. 05）,and they were significantly higher in the liver cancer group than those of the precancerous lesion group（ P〈0. 05）. The positive rate of γ-GT in the liver cancer group was significantly higher than that of AFP and CEA（ χ~2= 5. 952,P〈0. 05）. At the same time,the positive rate of AKP in the liver cancer group was significantly higher than that of CEA（ χ~2=7. 200,P〈0. 05）. In addition,the positive rates of AFP、CEA、γ-GT and AKP in the liver cancer group were significantly higher than those in the precancerous lesion group and control group（ P〈0. 05）. The sensitivity,specificity,positive predictive value and negative predictive value of combined detection of AFP＋ CEA＋AKP＋γ-GT were significantly higher than those of AFP＋CEA（ P〈0. 05）. Conclusion The expressions of AFP,CEA,AKP,γ-GT and SFe in patients with liver cancer,precancerous lesions and normal controls are different. The combined detection can improve the sensitivity and specificity of the diagnosis of liver cancer and can be used as an important reference index for the diagnosis of liver cancer.
作者
朱剑
师勇刚
ZHU Jian;SHI Yonggang(Magnetic Resonance Room,Central Hospital of Tongchuan Mine Bureau,Tongchuan Shaanxi 727000,Chin)
出处
《解放军预防医学杂志》
CAS
2018年第6期781-783,共3页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
陕西省社会发展科技攻关项目(No.015SF-1612-G)
关键词
肝癌
癌前病变
铁蛋白
碱性磷酸酶
liver cancer
precancerous lesions
ferritin
alkaline phosphatase
