摘要
目的探究大量输血对严重创伤患者凝血功能的影响。方法选取本院接收的52例严重创伤患者为研究对象,将其随机分为对照组与观察组,各26例。对照组患者输血量小于本身血容量的1倍,观察组患者输血量大于等于本身血容量的1.5倍。比较两组患者输血前、后的各项指标水平。结果输血前,两组患者的各项指标无明显差异(P>0.05);输血后1 d,观察组的PT、APTT、TT明显延长,而FIB、PLT明显降低,且与对照组比较差异显著(P<0.05);输血后6 d,两组患者的各项指标比较,差异无统计学意义(P>0.05)。对照组患者在输血前、输血后1、6 d的各项指标无明显变化(P>0.05)。结论严重创伤患者在大量输血后,凝血功能明显下降,应依照患者的具体状况进行血小板和血浆的补充,避免患者出现凝血功能障碍的现象,从而明显改善输血成效。
Objective To explore the effect of massive blood transfusion on the blood coagulation function of patients with severe trauma. Methods A total of 52 patients of severe trauma who were admitted in our hospital were selected as the research objects and randomly divided into control group（26 cases） and observation group（26 cases）. The volume of blood transfusion in the control group was less than 1 times of blood-volume, the volume of blood transfusion in the observation group was more than 1.5 times of blood-volume. The indexes before and after blood transfusion between the two groups were compared. Results Before transfusion, there were no significant differences in the indexes between the two groups（P〉0.05）; at1 d after transfusion, the PT, APTT and TT significantly prolonged, FIB and PLT significantly decreased in the observation group, which were significantly different from those in the control group（P 〈0.05）; at 6 d after transfusion, there were no statistical differences in above indexes between the two groups（P 〉0.05）. In the control group, there were no significant changes in the indexes before transfusion, at 1 and 6 d after transfusion（P〉0.05）. Conclusion The coagulation function of patients with severe trauma significantly decrease after massive transfusion. According to the specific condition of patients,the platelet and plasma are replenished to avoid the phenomenon of coagulation dysfunction, and the effect of blood transfusion can improve obviously.
作者
潘彬
林正明
PAN Bin, LIN Zheng-ming(Blood Transfusion Room, the First People＇s Hospital of Hefei, Hefei 230601, China)
出处
《临床医学研究与实践》
2018年第19期96-97,共2页
Clinical Research and Practice
关键词
大量输血
严重创伤
凝血功能
massive blood transfusion
severe trauma
coagulation function
